Nephrology Department, Loghman Hakim Hospital, Shahid Beheshti University Medical of Science, Tehran, Iran.
Health Services Management Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
J Complement Integr Med. 2022 Jun 3;19(3):531-541. doi: 10.1515/jcim-2022-0082. eCollection 2022 Sep 1.
An evaluation the effects of curcumin on inflammatory markers and lipid profiles among patients with chronic kidney diseases (CKD).
The electronic databases such as PubMed, and Scopus were searched systematically up until 12 December 2021. To evaluate the quality of the included studies, the Cochrane risk-of-bias tool for randomized trials was utilized. Likewise, data pooling was performed using a random effects model, also called a variance components model. Also, the findings were calculated as weighted mean difference (WMD) with a 95% confidence interval (CI).
In the end, this meta-analysis comprised a total number of nine studies. Curcumin intake significantly reduced total cholesterol (TC) (WMD=-13.77 mg/dL; 95% CI, -26.77, -0.77; p=0.04) and tumor necrosis factor alpha (TNF-α) (WMD=-18.87 pg/mL; 95% CI, -28.36, -9.38; p<0.001) compared with controls. The results did not confirm the significant effect of curcumin intake on triglyceride (TG) (WMD=-6.37 mg/dL; 95% CI, -26.59, 13.85; p=0.54), low-density lipoproteins (LDL-C) (WMD=-5.65 mg/dL; 95% CI, -20.81, 9.50; p=0.46), high-density lipoprotein (HDL-C) (WMD=0.16 mg/dL; 95% CI, -2.55, 2.88; p=0.91), and C-reactive protein (CRP) (WMD=-0.13 mg/L; 95% CI, -3.25, 3.30; p=0.93).
Our study showed that curcumin significantly impacts TC and TNF levels in CKD patients.
评估姜黄素对慢性肾脏病（CKD）患者炎症标志物和血脂谱的影响。
系统检索了 PubMed 和 Scopus 等电子数据库，检索截至 2021 年 12 月 12 日。为了评估纳入研究的质量，使用了 Cochrane 随机试验风险偏倚工具。同样，使用随机效应模型（也称为方差分量模型）进行了数据合并。此外，使用加权均数差值（WMD）和 95%置信区间（CI）计算结果。
最终，这项荟萃分析共纳入了 9 项研究。与对照组相比，姜黄素摄入可显著降低总胆固醇（TC）（WMD=-13.77mg/dL；95%CI，-26.77，-0.77；p=0.04）和肿瘤坏死因子-α（TNF-α）（WMD=-18.87pg/mL；95%CI，-28.36，-9.38；p<0.001）。结果并未证实姜黄素摄入对甘油三酯（TG）（WMD=-6.37mg/dL；95%CI，-26.59，13.85；p=0.54）、低密度脂蛋白胆固醇（LDL-C）（WMD=-5.65mg/dL；95%CI，-20.81，9.50；p=0.46）、高密度脂蛋白（HDL-C）（WMD=0.16mg/dL；95%CI，-2.55，2.88；p=0.91）和 C 反应蛋白（CRP）（WMD=-0.13mg/L；95%CI，-3.25，3.30；p=0.93）有显著影响。
本研究表明，姜黄素可显著影响 CKD 患者的 TC 和 TNF 水平。
