洛哌丁胺相关性坏死性小肠结肠炎

Loperamide associated necrotising enterocolitis.

作者信息

Chow C B, Li S H, Leung N K

出版信息

Acta Paediatr Scand. 1986 Nov;75(6):1034-6. doi: 10.1111/j.1651-2227.1986.tb10338.x.

DOI:10.1111/j.1651-2227.1986.tb10338.x

Abstract

Two cases of necrotising enterocolitis (NEC) occurring in infants beyond the neonatal period were reported. They did not have any predisposing factors to NEC but both had paralytic ileus after loperamide therapy for their mild diarrhoea prior to the onset of NEC. The possible role of loperamide in the pathogenesis of NEC was discussed.

摘要

报告了两例发生在新生儿期之后婴儿的坏死性小肠结肠炎（NEC）病例。他们没有任何NEC的诱发因素，但在NEC发病前，两人在使用洛哌丁胺治疗轻度腹泻后均出现了麻痹性肠梗阻。讨论了洛哌丁胺在NEC发病机制中的可能作用。