Department of Cardiology, Affiliated Hospital 2 of Nantong University.
Department of Pharmacy, Affiliated Hospital 2 of Nantong University.
Int Heart J. 2022;63(3):454-458. doi: 10.1536/ihj.21-769.
Laminin is a major component of the basement membrane of cardiomyocytes and has been found at a high level in patients with heart failure. However, detailed information on the relationship between disease management and progression in patients with acute heart failure (AHF) remains lacking. We focused on the levels of laminin (LN) before and after admission to the hospital in AHF patients. One hundred twelve AHF patients who were hospitalized in the Affiliated Hospital 2 of Nantong University from January 2020 to February 2021 were selected as the main subjects of the study. The control group consisted of 137 hospitalized patients in New York Heart Association (NYHA) classes I-II during the same time period. Serum laminin levels were measured at baseline in all patients. Besides, laminin levels of AHF patients were measured again 1 week after admission. The serum laminin levels at admission were significantly higher in AHF patients than those in the patients of NYHA classes I-II [73.79 (41.04, 129.75) ng/mL versus 27.98 (20.75, 37.49) ng/mL, respectively, P < 0.001]. After 1 week of treatment, laminin levels in AHF patients were 41.56 (27.92, 78.67) ng/mL, which was significantly lower than before treatment (Z = -6.357, P < 0.001). Bivariate linear correlation analysis showed that LN was associated with NT-proBNP both in the acute phase and after treatment. Laminin levels were significantly higher in AHF patients who had atrial fibrillation (AF) than in those without AF. As a result, we speculated that laminin reflected improved heart function and the occurrence of myocardial fibrosis.
层粘连蛋白是心肌细胞基底膜的主要成分，在心力衰竭患者中发现其水平较高。然而，关于急性心力衰竭（AHF）患者疾病管理与进展之间的详细关系仍缺乏信息。我们专注于 AHF 患者入院前后层粘连蛋白（LN）的水平。选择 2020 年 1 月至 2021 年 2 月期间在南通大学附属医院住院的 112 例 AHF 患者作为主要研究对象。对照组由同期纽约心脏协会（NYHA）I-II 级住院患者 137 例组成。所有患者入院时均测量血清层粘连蛋白水平。此外，再次测量 AHF 患者入院后 1 周的层粘连蛋白水平。与 NYHA I-II 级患者相比，AHF 患者入院时的血清层粘连蛋白水平显著升高[73.79（41.04，129.75）ng/ml 比 27.98（20.75，37.49）ng/ml，P<0.001]。经过 1 周的治疗，AHF 患者的层粘连蛋白水平为 41.56（27.92，78.67）ng/ml，明显低于治疗前（Z=-6.357，P<0.001）。双变量线性相关分析表明，LN 与急性期和治疗后 NT-proBNP 均相关。伴心房颤动（AF）的 AHF 患者的层粘连蛋白水平明显高于不伴 AF 的患者。因此，我们推测层粘连蛋白反映了心脏功能的改善和心肌纤维化的发生。
