Department of General Practice, Affiliated Hospital 2 of Nantong University, Nantong, China.
Department of Cardiology, Affiliated Hospital 2 of Nantong University, Nantong, China.
Clin Cardiol. 2023 Jul;46(7):818-822. doi: 10.1002/clc.24056. Epub 2023 May 31.
To investigate the correlation between serum laminin (LN) level and the prognosis of acute heart failure (AHF).
A total of 199 patients with AHF treated in Nantong First People's Hospital from March 2019 to November 2021 were included in this study. The patients were divided into the event group and the non-event group according to whether major adverse cardiovascular events (MACEs) occurred during hospitalization. We collected the baseline data of all patients and their LN levels were measured. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of LN for the occurrence of MACE in AHF patients during hospitalization. Multivariate Logistic regression analysis was used to screen the independent factors associated with the occurrence of MACE in patients with AHF.
Among 199 patients with AHF, 43 were in the event group and 156 were in the non-event group. The area under ROC curve of LN to predict MACE in AHF patients during hospitalization was 0.8144, 95% confidence interval (CI): 0.7433-0.8855, p < .0001, cutoff point = 77.9, specificity 58.33%, and sensitivity 88.37%. Multivariate logistic regression analysis showed that the independent factors associated with the occurrence of MACE in AHF patients were the increase of LN level (odds ratio [OR]: 1.020, 95% CI: 1.012-1.028), the decrease of ejection fraction (OR: 0.007, 95% CI: 0.000-0.362) and diastolic blood pressure (OR: 0.946, 95% CI: 0.913-0.981; p < .05).
The increase of LN level is independently correlated with the occurrence of MACE in AHF patients during hospitalization, which has the potential to be a serological indicator for poor prognosis in patients with AHF.
探讨血清层粘连蛋白（LN）水平与急性心力衰竭（AHF）预后的相关性。
选取 2019 年 3 月至 2021 年 11 月在南通市第一人民医院治疗的 199 例 AHF 患者为研究对象，根据住院期间是否发生主要不良心血管事件（MACE）将患者分为事件组和非事件组。收集所有患者的基线资料并检测其 LN 水平，采用受试者工作特征（ROC）曲线分析 LN 对 AHF 患者住院期间发生 MACE 的预测价值，采用多因素 Logistic 回归分析筛选与 AHF 患者发生 MACE 相关的独立因素。
199 例 AHF 患者中，43 例发生事件，156 例未发生事件。LN 预测 AHF 患者住院期间发生 MACE 的 ROC 曲线下面积为 0.8144，95%置信区间（CI）：0.7433-0.8855，p<0.0001，截断点=77.9，特异度 58.33%，灵敏度 88.37%。多因素 Logistic 回归分析显示，与 AHF 患者发生 MACE 相关的独立因素是 LN 水平升高（比值比[OR]：1.020，95%CI：1.012-1.028）、射血分数降低（OR：0.007，95%CI：0.000-0.362）和舒张压降低（OR：0.946，95%CI：0.913-0.981；p<0.05）。
LN 水平升高与 AHF 患者住院期间发生 MACE 独立相关，有望成为 AHF 患者预后不良的血清学指标。
