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复苏的遗忘。

Revival of the Forgotten.

机构信息

Department of Cardiology, University Heart and Vascular Center Hamburg.

Institute of Cardiovascular Sciences, University of Birmingham.

出版信息

Int Heart J. 2022;63(3):504-509. doi: 10.1536/ihj.21-844.

Abstract

Pulmonary vein (PV) isolation (PVI) by continuous, transmural and durable lesions is decisive for ensuring long-term freedom from atrial fibrillation (AF). AF ablation requires irrigated tip catheters to reduce thromboembolic complications. This precluded temperature-controlled delivery of radiofrequency (RF) energy.The aim of this study was to evaluate feasibility, acute efficacy, and safety of an irrigated, temperature-controlled ablation catheter [DiamondTemp™ (DT) Medtronic] for PVI.Consecutive patients with AF underwent PVI using the DT catheter combined with high-power short-duration RF applications. Ablation settings were (1) a catheter tip temperature limit of 60°C, (2) a temperature-controlled power of 50 W, and (3) application duration of 10 seconds. The primary endpoint was acute isolation of PVs, reassessed after a 30-minute waiting period. Secondary endpoints included procedural parameters (defined as a catheter tip temperature of 50°C > 3 seconds, an impedance drop of 5-10 Ω) and the occurrence of serious adverse events.Fifty consecutive patients [mean age 66 ± 12 years, 38 (76%) women, 24 patients with paroxysmal AF (48%)] were included. Median procedure and left atrial dwell time was 89 [68; 107] and 63 [52; 79] minutes, respectively. Mean number of RF applications was 59 ± 20, and mean total RF duration was 14 ± 6 minutes. Acute PVI was achieved in all patients solely using DT ablation. Acute PV reconnection within the waiting period occurred in five patients; all reconnected PVs were successfully reisolated. One major complication occurred.In this study, the DT ablation system demonstrated high acute efficacy for PVI. Temperature-controlled ablation in conjunction with high-power short-duration applications might be effectively supported.

摘要

肺静脉(PV)隔离(PVI)通过连续、透壁和持久的病变对于确保长期无房颤(AF)至关重要。AF 消融需要使用灌流尖端导管来降低血栓栓塞并发症。这排除了温度控制下射频(RF)能量的输送。本研究旨在评估一种灌流、温度控制消融导管[DiamondTemp™(DT)Medtronic]用于 PVI 的可行性、急性疗效和安全性。连续的 AF 患者接受了使用 DT 导管结合高功率短时间 RF 应用的 PVI。消融设置为(1)导管尖端温度限制为 60°C,(2)温度控制功率为 50 W,(3)应用持续时间为 10 秒。主要终点是 PV 的急性隔离,在 30 分钟等待期后重新评估。次要终点包括程序参数(定义为导管尖端温度为 50°C > 3 秒,阻抗下降 5-10 Ω)和严重不良事件的发生。连续 50 例患者[平均年龄 66 ± 12 岁,38 例(76%)女性,24 例阵发性 AF(48%)]纳入研究。中位手术和左心房停留时间分别为 89 [68;107]和 63 [52;79]分钟。RF 应用的平均次数为 59 ± 20,总 RF 持续时间的平均为 14 ± 6 分钟。所有患者均仅使用 DT 消融成功实现了急性 PVI。在等待期间发生了 5 例急性 PV 再连接,所有再连接的 PV 均成功再隔离。发生了 1 例主要并发症。在本研究中,DT 消融系统对 PVI 的急性疗效很高。结合高功率短时间应用的温度控制消融可能会得到有效支持。

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