The relationships of childhood socio-demographic factors and early parental loss to major depression in adult life.

Sixty middle-aged urban women with a major depressive episode (DSM-III) diagnosed in a community survey were compared with those 400 participants of the study who had no history of major depression. There were no significant differences between groups regarding most childhood demographic variables such as grade of urbanization, social class, school education, size of sibship and ordinal position. The subjects with major depression and especially those with melancholia had experienced parental loss before age 17 significantly more often than had the controls. This difference dealt only with parental divorce and other separations but not with parental death. There were no significant differences regarding parental death between melancholics, non-melancholic major depressives and controls.