KNCV Tuberculosis foundation, Technical division, The Hague, The Netherlands, Department of Global Health and Amsterdam Institute for Global Health and Development, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
KNCV Tuberculosis foundation, Technical division, The Hague, The Netherlands.
Int J Tuberc Lung Dis. 2022 Jun 1;26(6):529-536. doi: 10.5588/ijtld.21.0607.
Protection against infection by the bacille Calmette-Guérin vaccine against remains a subject of controversy. We investigated the association between BCG vaccination at birth and infection by . This was a secondary analysis of data from tuberculin skin test (TST) surveys in Vietnamese schoolchildren between 1988 and 2001. We investigated whether a BCG scar was associated with a lower prevalence of TST positivity, adjusting for BCG-induced variation by varying cut-off values for a positive TST. We found a positive association between BCG scar and TST positivity. The strength of the association decreased with increasing TST cut-off values; however, it never inverted significantly, irrespective of geographic region and survey year. In Vietnam, BCG vaccination was not associated with reduced infection prevalence as measured using TST. This in contrary to a similar study conducted in Tanzania. These contradictory findings may be explained by geographical differences and the relatively high prevalence in Vietnam of the Beijing genotype, which is reported to be capable of circumventing BCG-induced immunity.
卡介苗（BCG）疫苗预防感染的效果仍然存在争议。我们研究了出生时接种卡介苗与结核分枝杆菌感染之间的关系。这是对 1988 年至 2001 年期间越南学童结核菌素皮肤试验（TST）调查数据的二次分析。我们通过改变 TST 阳性的截断值来调整 BCG 诱导的变异，调查了 BCG 疤痕是否与 TST 阳性率较低有关。我们发现 BCG 疤痕与 TST 阳性之间存在正相关。随着 TST 截断值的增加，关联强度降低；然而，无论地理区域和调查年份如何，这种关联从未发生显著逆转。在越南，BCG 疫苗接种与 TST 测量的结核分枝杆菌感染患病率降低无关。这与在坦桑尼亚进行的类似研究结果相反。这些相互矛盾的发现可能是由于地理差异以及越南报道的能够规避 BCG 诱导免疫的北京基因型的相对较高流行率所致。
