曲美布汀对豚鼠离体回肠抽搐反应的阿片样抑制作用。
Opiate-like inhibitory effect of trimebutine on the twitch response of the isolated guinea pig ileum.
作者信息
Yamasato T, Takaki M, Nakayama S
出版信息
Acta Med Okayama. 1987 Feb;41(1):33-5. doi: 10.18926/AMO/31771.
PMID:3565073
Abstract
Trimebutine at low concentrations (6 X 10(-9)-1.4 X 10(-8) M) slightly enhanced the twitch response of isolated guinea pig ileum induced by transmural stimulation. At high concentrations (2 X 10(-8)-2 X 10(-7) M), however, it inhibited the twitch response in a dose dependent manner. This inhibitory effect of trimebutine was reversed by naloxone (8.1 X 10(-9) M). These results suggest that trimebutine has an opiate-like action on the myenteric plexus.
摘要
低浓度（6×10⁻⁹ - 1.4×10⁻⁸ M）的曲美布汀可轻微增强透壁刺激诱导的离体豚鼠回肠的抽搐反应。然而，在高浓度（2×10⁻⁸ - 2×10⁻⁷ M）时，它以剂量依赖性方式抑制抽搐反应。曲美布汀的这种抑制作用可被纳洛酮（8.1×10⁻⁹ M）逆转。这些结果表明曲美布汀对肠肌间神经丛具有阿片样作用。
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