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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Martin M I, Colado M I, Alfaro M J

Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Madrid, Spain.

Gen Pharmacol. 1991;22(1):73-5. doi: 10.1016/0306-3623(91)90311-s.

The relationship between salmon calcitonin (S-CT) and opioid system was studied in isolated guinea-pig ileum. 2. Addition of S-CT (0.1 to 1.6 U/ml) to the organ bath did not modify the amplitude of the contractile response induces by electrical stimulation. 3. However, when tissues were incubated 30 min with S-CT (0.1 U/ml), the inhibitory effect of the release of endogenous opioids, met-enkephalin (1 microM) and morphine (0.2 microM) was significantly increased. 4. Our results suggest that some of the analgesic effects of S-CT could be attributed to an up-regulation of the opioid receptors.

在离体豚鼠回肠中研究了鲑鱼降钙素（S-CT）与阿片系统之间的关系。2. 向器官浴槽中添加S-CT（0.1至1.6 U/ml）不会改变电刺激诱导的收缩反应幅度。3. 然而，当组织与S-CT（0.1 U/ml）孵育30分钟时，内源性阿片类物质甲硫氨酸脑啡肽（1 microM）和吗啡（0.2 microM）释放的抑制作用显著增强。4. 我们的结果表明，S-CT的一些镇痛作用可能归因于阿片受体的上调。

Martin M I, Colado M I, Alfaro M J

Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Madrid, Spain.

Gen Pharmacol. 1991;22(1):73-5. doi: 10.1016/0306-3623(91)90311-s.

The relationship between salmon calcitonin (S-CT) and opioid system was studied in isolated guinea-pig ileum. 2. Addition of S-CT (0.1 to 1.6 U/ml) to the organ bath did not modify the amplitude of the contractile response induces by electrical stimulation. 3. However, when tissues were incubated 30 min with S-CT (0.1 U/ml), the inhibitory effect of the release of endogenous opioids, met-enkephalin (1 microM) and morphine (0.2 microM) was significantly increased. 4. Our results suggest that some of the analgesic effects of S-CT could be attributed to an up-regulation of the opioid receptors.

在离体豚鼠回肠中研究了鲑鱼降钙素（S-CT）与阿片系统之间的关系。2. 向器官浴槽中添加S-CT（0.1至1.6 U/ml）不会改变电刺激诱导的收缩反应幅度。3. 然而，当组织与S-CT（0.1 U/ml）孵育30分钟时，内源性阿片类物质甲硫氨酸脑啡肽（1 microM）和吗啡（0.2 microM）释放的抑制作用显著增强。4. 我们的结果表明，S-CT的一些镇痛作用可能归因于阿片受体的上调。