Wang Hsuan-Chin, Grolman Joshua M, Rizvi Aoon, Hisao Grant S, Rienstra Chad M, Zimmerman Steven C
Department of Chemistry, ‡Beckman Institute for Advanced Science and Technology, and §Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Department of Chemistry, Beckman Institute for Advanced Science and Technology, and §Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
ACS Macro Lett. 2017 Mar 21;6(3):321-325. doi: 10.1021/acsmacrolett.6b00968. Epub 2017 Mar 10.
The majority of current pH-triggered release systems is designed to respond to either low or high pH. Encapsulants based on polyampholytes are an example of materials that can respond to both acidic and basic pH. However, polyampholyte-based encapsulants generally possess a low loading capacity and have difficulty retaining their small-molecule cargo. The current work utilizes interfacial polymerization between polyamines and a pyromellitic diester diacid chloride to form high capacity "liquid core-shell" polyamide microcapsules that are stable in a dry or nonpolar environment but undergo steady, controlled release at pH 7.4 and accelerated release at pH 5 and pH 10. The rate of release can be tuned by adjusting the amine cross-linker feed ratio, which varies the degree of cross-linking in the polymer shell. The thin-shell microcapsule exhibited suitable barrier properties and tunable dual acid/base-triggered release, with applications in a wide range of pH environments.
当前大多数pH触发释放系统设计为对低pH或高pH作出响应。基于聚两性电解质的封装材料是能够对酸性和碱性pH都作出响应的材料示例。然而，基于聚两性电解质的封装材料通常具有较低的负载能力，并且难以保留其小分子货物。当前的工作利用多胺与均苯四甲酸二酰氯之间的界面聚合形成高容量的“液芯壳”聚酰胺微胶囊，这些微胶囊在干燥或非极性环境中稳定，但在pH 7.4时会进行稳定、可控的释放，在pH 5和pH 10时会加速释放。释放速率可以通过调整胺交联剂进料比来调节，这会改变聚合物壳中的交联程度。薄壳微胶囊表现出合适的阻隔性能和可调的双酸/碱触发释放，适用于广泛的pH环境。
