College of Food Science and Engineering, Ocean University of China, Qingdao, China.
College of Food Science and Engineering, Ocean University of China, Qingdao, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, Shandong Province, PR China.
Food Res Int. 2022 Jun;156:111324. doi: 10.1016/j.foodres.2022.111324. Epub 2022 May 4.
Astaxanthin has been widely favored as a health food supplement by individuals but its absorption in the body seems not to be satisfactory. In addition, the peak time of astaxanthin derived from Haematococcus pluvialis in the plasma was much longer than other carotenoids found in our previous research. Thus, it is necessary to explore the process that affects the absorption of astaxanthin in order to potentially find a novel approach to improve the absorption in the future. In this study, we confirmed that the colon has an ability to absorb astaxanthin and conducted acute feeding experiments with the treatment of antibiotics in C57BL/6J mice and chronic feeding experiments in germ-free (GF) mice to detect the relationship between the gut microbiota and the absorption of astaxanthin. Our study showed that the decrease of gut microbiota led to a less oral absorbability, which might be related to the decreased expression of SR-BI in the small intestine and the reduction of free form and Z-astaxanthin converted by the gut microbiota found in the vitro culture. The experiments of anaerobic culture also implied that Lactobacillus might play an important role in the absorption of astaxanthin.
虾青素作为一种健康食品补充剂受到了广泛的青睐，但它在体内的吸收似乎并不令人满意。此外，雨生红球藻来源的虾青素在血浆中的达峰时间比我们之前研究中发现的其他类胡萝卜素长得多。因此，有必要探索影响虾青素吸收的过程，以便将来有可能找到一种提高吸收的新方法。在这项研究中，我们证实了结肠具有吸收虾青素的能力，并在 C57BL/6J 小鼠中进行了急性喂养实验，用抗生素处理，并在无菌（GF）小鼠中进行了慢性喂养实验，以检测肠道微生物群与虾青素吸收之间的关系。我们的研究表明，肠道微生物群的减少导致口服吸收能力下降，这可能与小肠中 SR-BI 的表达减少以及体外培养中发现的由肠道微生物群转化的游离形式和 Z-虾青素减少有关。厌氧培养实验还暗示，乳酸菌可能在虾青素的吸收中发挥重要作用。
