Nutrition Unit, Product Development and Advisory Technical Services Department, Malaysian Palm Oil Board, No. 6, Persiaran Institusi, Bandar Baru Bangi 43000, Selangor, Malaysia.
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.
Food Res Int. 2022 Jun;156:111175. doi: 10.1016/j.foodres.2022.111175. Epub 2022 Mar 21.
Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that are comparable to or exceed those of tocopherols (Toc). Notably, T3 must be consumed as it cannot be produced by the human body. Here, we reviewed the anti-inflammatory activities of T3s in the prevention and treatment of various inflammatory disorders; focusing on recent preclinical and clinical studies. There is compelling data from experimental models and human studies that shows that T3 administration can inhibit the release of various inflammatory mediators that contribute to age-related disease by enhancing oxidative stress, reducing melanin production and skin damage, and preventing cardiovascular disease and stroke. There is evidence to show that T3s possess neuroprotective, anticancer, and anti-osteoporosis properties. In addition, T3s also protect the gastrointestinal tract, facilitate blood glucose control in people with diabetes, and prevent fatty liver disease. Furthermore, results from some clinical studies suggest that T3s are beneficial nutritional supplements with no evident side-effects when administered to patients with neurological or cardiovascular disorders. There is growing evidence from clinical trials that shows that T3s can help prevent dementia and Alzheimer's disease. More well-designed clinical trials, as well as human intervention studies, are required to confirm the health benefits of palm T3.
棕榈油富含生育三烯酚（T3s），这是一种维生素 E，因其具有抗炎和抗氧化特性而备受关注，其特性可与生育酚（Toc）相媲美，甚至超过生育酚。值得注意的是，T3 必须通过摄入才能被人体吸收，因为人体无法自行产生 T3。在这里，我们综述了 T3 在预防和治疗各种炎症性疾病中的抗炎作用，重点介绍了最近的临床前和临床研究。有大量来自实验模型和人体研究的数据表明，T3 的给药可以通过增强氧化应激、减少黑色素生成和皮肤损伤、预防心血管疾病和中风来抑制各种炎症介质的释放，这些炎症介质与年龄相关疾病的发生有关。有证据表明 T3 具有神经保护、抗癌和抗骨质疏松特性。此外，T3 还可以保护胃肠道，促进糖尿病患者的血糖控制，并预防脂肪肝疾病。此外，一些临床研究的结果表明，T3 是一种有益的营养补充剂，当给予患有神经或心血管疾病的患者时，没有明显的副作用。越来越多的临床试验证据表明，T3 有助于预防痴呆症和阿尔茨海默病。需要进行更多设计良好的临床试验和人体干预研究，以确认棕榈 T3 的健康益处。
