AlShehri Sara, Alajmi Sarah, Ekhzaimy Aishah, Aldawas Sadeem, Alalwan Maryam
Endocrinology, Diabetes and Metabolism, King Saud University, Riyadh, SAU.
Internal Medicine/Adult Endocrinology, King Saud University, Riyadh, SAU.
Cureus. 2022 Apr 28;14(4):e24570. doi: 10.7759/cureus.24570. eCollection 2022 Apr.
Thyroid storm (TS) is a rare and life-threatening medical emergency, most commonly caused by Graves' disease (GD). GD can be induced by immune reconstitution therapy (IRT) such as alemtuzumab (ALZ), a humanized monoclonal antibody against CD52, which is shown to be effective in the treatment of relapsing-remitting multiple sclerosis (RRMS). Here, we present a rare case of TS developing in a 39-year-old female with ALZ-induced GD, managed with antithyroid medication followed by thyroidectomy. There is some evidence that ALZ-induced GD may behave less aggressively than conventional GD. However, physicians should be aware that severe thyrotoxicosis and thyroid storm can happen, which requires prompt recognition and aggressive therapy.
甲状腺风暴（TS）是一种罕见且危及生命的医疗急症，最常见由格雷夫斯病（GD）引起。GD可由免疫重建治疗（IRT）诱发，如阿仑单抗（ALZ），一种抗CD52的人源化单克隆抗体，已证明其在治疗复发缓解型多发性硬化症（RRMS）方面有效。在此，我们报告一例罕见病例，一名39岁女性因ALZ诱发GD而发生甲状腺风暴，先采用抗甲状腺药物治疗，随后进行了甲状腺切除术。有证据表明，ALZ诱发的GD可能比传统GD的侵袭性小。然而，医生应意识到严重甲状腺毒症和甲状腺风暴可能发生，这需要及时识别并积极治疗。
