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中国人群中2型糖尿病合并重度抑郁症患者的5-羟色胺受体1A基因多态性

HTR1A Gene Polymorphism in Type 2 Diabetes Mellitus Comorbid with Major Depressive Disorder in a Chinese Population.

作者信息

Simayi Dilixia, Guan Yaqun

机构信息

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Key Laboratory of Molecular Biology for Endemic Diseases, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.

Department of Oncology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China.

出版信息

Diabetes Metab Syndr Obes. 2022 May 25;15:1597-1604. doi: 10.2147/DMSO.S361843. eCollection 2022.

DOI:10.2147/DMSO.S361843
PMID:35651901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9148918/
Abstract

BACKGROUND

Major depressive disorder is a frequent mental illness, which is common in patients with type 2 diabetes. Type 2 diabetes comorbid with depression has a worse prognosis. There are multiple risk factors for depression, and genetic studies have shown that gene polymorphism may play an important role in the pathogenesis of depression.

METHODS

A total of 874 patients with type 2 diabetes were recruited for this study and divided into two groups: depressive group (DDM group, n = 234) and non-depressive group (NDDM group, n = 640). HTR1A gene polymorphisms (rs6295, rs878567, rs1800044) genotyping work was performed using a custom by design 48-Plex SNPscan Kit.

RESULTS

The rs6295, rs878567, and rs1800044 SNPs were not associated with type 2 diabetes comorbid with depression. Female sex, age, and FBG level increased the risk of depression in patients with type 2 diabetes.

CONCLUSION

HTR1A rs6295, rs878567, and rs1800044 SNPs polymorphism is not associated with type 2 diabetes comorbid with depression. Rather, female sex, age, and FBG level are risk factors for depression among patients with type 2 diabetes. Larger studies are needed to further confirm our findings.

摘要

背景

重度抑郁症是一种常见的精神疾病，在2型糖尿病患者中很普遍。2型糖尿病合并抑郁症的预后较差。抑郁症有多种风险因素，基因研究表明基因多态性可能在抑郁症的发病机制中起重要作用。

方法

本研究共招募了874例2型糖尿病患者，分为两组：抑郁组（DDM组，n = 234）和非抑郁组（NDDM组，n = 640）。使用定制的48重SNPscan试剂盒进行5-羟色胺受体1A（HTR1A）基因多态性（rs6295、rs878567、rs1800044）基因分型工作。

结果

rs6295、rs878567和rs1800044单核苷酸多态性与2型糖尿病合并抑郁症无关。女性、年龄和空腹血糖水平增加了2型糖尿病患者患抑郁症的风险。

结论

HTR1A基因的rs6295、rs878567和rs1800044单核苷酸多态性与2型糖尿病合并抑郁症无关。相反，女性、年龄和空腹血糖水平是2型糖尿病患者患抑郁症的风险因素。需要更大规模的研究来进一步证实我们的发现。