All India Institute of medical Sciences, New Delhi, India.
All India Institute of medical Sciences, New Delhi, India.
Asian J Psychiatr. 2019 Jun;43:184-188. doi: 10.1016/j.ajp.2019.05.028. Epub 2019 May 17.
Major Depressive Disorder (MDD) is a broad heterogeneous diagnostic construct. Previous studies have shown that it can be resolved into several symptom-clusters which are proposed to be associated with single nucleotide polymorphisms (SNPs) of the serotonergic pathway (5-HTTLPR, 5HTR1A, 5-HTR2A).
In a cross-sectional study conducted at a tertiary level mental health care set-up in north India, 80 out-patients with MDD were evaluated with Montgomery Asberg Depression Rating Scale (MADRS) and then genotyping was done. The different clinical and genetic variables were compared across the factor structures of MADRS. Also, the comparison of the genetic data of cases was done with the pre-existing database of the non-blood related healthy ethnically-matched controls.
There was no significant association between age, gender, other clinical variables, SNPs like 5-HTTLPR SS/SL, rs6295 CC/CG/GG, rs6311GG/GA/AA, rs6313 CC/CT/TT and different factor-structures like 'detachment' consisting of items like concentration difficulty, lassitude, inability to feel; 'psychic anxiety' consisting of suicidal thoughts and inner tension; 'mood-pessimism' consisting of symptoms like apparent sadness, reported sadness, pessimistic thoughts and 'vegetative symptoms' like decreased sleep, poor appetite. Neither there was any association between genotype of the cases compared with the controls.
No significant association was obtained between the four-factor structures of depression in MADRS and serotonin transporter and receptor SNPs in a study with a small sample size. This study evaluates whether depression symptom-clusters have distinct genotypic determinants and necessitates more comprehensive studies for unravelling the genetic determinants of depression.
重度抑郁症（MDD）是一个广泛的异质诊断结构。先前的研究表明，它可以分为几个症状群，这些症状群被认为与 5-羟色胺能途径的单核苷酸多态性（5-HTTLPR、5HTR1A、5-HTR2A）有关。
在印度北部一家三级精神保健机构进行的横断面研究中，对 80 名 MDD 门诊患者进行了蒙哥马利抑郁评定量表（MADRS）评估，然后进行了基因分型。比较了 MADRS 不同因子结构中的不同临床和遗传变量。此外，还比较了病例的遗传数据与非血缘关系的、种族匹配的健康对照的现有数据库。
年龄、性别、其他临床变量、5-HTTLPR SS/SL、rs6295 CC/CG/GG、rs6311 GG/GA/AA、rs6313 CC/CT/TT 等 SNP 与“分离”（包括注意力困难、疲倦、无法感觉等症状）、“精神焦虑”（包括自杀念头和内心紧张等症状）、“情绪悲观”（包括明显悲伤、报告悲伤、悲观思想等症状）和“植物性症状”（包括睡眠减少、食欲不佳等症状）等不同因子结构之间没有显著相关性。病例的基因型与对照组之间也没有任何关联。
在这项小规模样本研究中，MADRS 的四因子结构与 5-羟色胺转运体和受体 SNP 之间没有显著相关性。本研究评估了抑郁症状群是否具有不同的基因型决定因素，并需要更全面的研究来揭示抑郁的遗传决定因素。
