双J管相关感染糖尿病患者病原菌的分布及耐药性

Distribution and Drug Resistance of Pathogenic Bacteria in Diabetic Patients with Double J-Stent Associated Infections.

作者信息

Zeng Ke, Huang Jun, Li Xiaobin, Ye Junbing, Yang Jian, Zhang Suchuan

机构信息

Department of Basic Medicine, Sichuan Vocational College of Health and Rehabilitation, Zigong, Sichuan, People's Republic of China.

Department of Urology, First People's Hospital of Zigong City, Zigong, Sichuan, People's Republic of China.

出版信息

Infect Drug Resist. 2022 May 25;15:2671-2678. doi: 10.2147/IDR.S360086. eCollection 2022.

DOI:10.2147/IDR.S360086

PMID:35652084

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9148917/

Abstract

OBJECTIVE

To analyze the distribution and drug resistance of pathogenic bacteria in diabetic patients with double J-stent associated infections, and to explore the strategies for prevention and treatment of the infections.

METHODS

From January 2019 to December 2021, 266 diabetic patients treated with double J-stent placement in our hospital assessed for eligibility were recruited. Urine and double J-stent samples were collected for pathogenicity assay and screened for biofilm bacteria. Pathogenic bacteria distribution and drug resistance were examined.

RESULTS

A total of 97 strains (36.5%) of pathogenic bacteria were isolated from urine samples and 129 strains (48.5%) from double J-stent samples (P > 0.05). 3 strains (1.1%) of biofilm bacteria were separated from urine samples and 106 strains (39.8%) from double J-stent samples (P < 0.05). In the double J-stent samples, there were significantly higher ratios of Gram-positive bacteria separated from biofilm bacteria versus the urine-cultured pathogens (44.3%/61.3%, P < 0.05), and higher drug resistance was observed in biofilm bacteria versus urine-cultured pathogens (P < 0.05). Fosfomycin tromethamine showed remarkable susceptibility to both urinary cultured pathogens and double J-stent biofilm bacteria.

CONCLUSION

Diabetic patients with double J-stent biofilm-positive bacteria are mainly Gram-positive bacteria, which are prone to biofilm formation and show strong drug resistance.

摘要

目的

分析双J管相关感染糖尿病患者病原菌分布及耐药情况，探讨感染防治策略。

方法

选取2019年1月至2021年12月在我院行双J管置入术且符合入选标准的266例糖尿病患者。收集尿液及双J管样本进行病原菌检测及生物被膜菌筛查，检测病原菌分布及耐药情况。

结果

尿液样本分离出病原菌97株（36.5%），双J管样本分离出129株（48.5%）（P>0.05）。尿液样本分离出生物被膜菌3株（1.1%），双J管样本分离出106株（39.8%）（P<0.05）。双J管样本中，生物被膜菌分离出的革兰阳性菌比例显著高于尿液培养病原菌（44.3%/61.3%，P<0.05），生物被膜菌耐药性高于尿液培养病原菌（P<0.05）。磷霉素氨丁三醇对尿液培养病原菌及双J管生物被膜菌均显示出显著敏感性。