Chen Hui, Yang Lin, Cheng Lin, Hu Xiao-Hua, Shen Yu-Ming
Department of Burns and Plastic Surgery, Beijing Jishuitan Hospital, Beijing 100035, China.
Department of Healthcare Associated Infection Control, Beijing Jishuitan Hospital, Beijing 100035, China.
World J Clin Cases. 2021 Apr 6;9(10):2228-2237. doi: 10.12998/wjcc.v9.i10.2228.
In this study, recent trends in the distribution and drug resistance of pathogenic bacteria isolated from patients treated at a burn ward between 2006 and 2019 were investigated.
To develop more effective clinical strategies and techniques for the prevention and treatment of bacterial infections in burn patients.
Clinical samples with positive bacteria were collected from patients at the burn ward in Beijing Jishuitan Hospital in China between January 2006 and December 2019. The samples were retrospectively analyzed, the distribution of pathogenic bacteria was determined, and the trends and changes in bacterial drug resistance during different period were assessed. Drug resistance in several main pathogenic bacteria from 2006 to 2011 and from 2012 to 2019 was comparatively summarized and analyzed.
Samples from 17119 patients were collected and analyzed from 2006 to 2019. Surprisingly, a total of 7960 strains of different pathogenic bacteria were isolated at this hospital. Among these bacteria, 87.98% (7003/7960) of the strains were isolated from burn wounds, and only 1.34% (107/7960) were isolated from the blood of patients. In addition, 49.70% (3956/7960) were identified as Gram-positive bacteria, 48.13% (3831/7960) were Gram-negative bacteria, and the remaining 2.17% (173/7960) were classified as fungi or other pathogens. Importantly, (21.68%), (14.23%), and (9.61%) were the top three pathogens most frequently isolated from patients.
In patients treated at the burn ward in this hospital from 2006 to 2019, and were the predominant clinical pathogens responsible for bacterial infections. The circumstantial detection and detailed monitoring of the intensity and growth of different pathogenic bacteria in clinical patients as well as tests of drug sensitivity during burn recovery are particularly important to provide guidelines for the application of antibiotics and other related drugs. Careful collection and correct, standard culture of bacterial specimens are also crucial to improve the efficiency of bacterial infection detection. Effective monitoring and timely clinical treatment in patients may help reduce the possibility and rate of infection as well as alleviate the effects of drug resistance among patients in burn centers.
本研究调查了2006年至2019年期间在烧伤病房接受治疗的患者分离出的病原菌的分布及耐药性的近期趋势。
制定更有效的临床策略和技术，以预防和治疗烧伤患者的细菌感染。
收集2006年1月至2019年12月期间中国北京积水潭医院烧伤病房患者的细菌阳性临床样本。对样本进行回顾性分析，确定病原菌的分布，并评估不同时期细菌耐药性的趋势和变化。对2006年至2011年以及2012年至2019年期间几种主要病原菌的耐药性进行了比较总结和分析。
2006年至2019年共收集并分析了17119例患者的样本。令人惊讶的是，该医院共分离出7960株不同的病原菌。其中，87.98%（7003/7960）的菌株是从烧伤创面分离出来的，只有1.34%（107/7960）是从患者血液中分离出来的。此外，49.70%（3956/7960）被鉴定为革兰氏阳性菌，48.13%（3831/7960）为革兰氏阴性菌，其余2.17%（173/7960）被归类为真菌或其他病原体。重要的是，（21.68%）、（14.23%）和（9.61%）是从患者中最常分离出 的三大病原菌。
在该医院2006年至2019年烧伤病房接受治疗的患者中，和是导致细菌感染的主要临床病原菌。在烧伤恢复过程中，对临床患者不同病原菌的强度和生长情况进行间接检测和详细监测以及药敏试验，对于提供抗生素及其他相关药物的应用指南尤为重要。仔细收集并正确、规范地培养细菌标本对于提高细菌感染检测效率也至关重要。对患者进行有效的监测和及时的临床治疗可能有助于降低感染的可能性和发生率，并减轻烧伤中心患者的耐药影响。
