Okabe Asako, Ishida Mitsuaki, Noda Yuri, Okano Kimiaki, Sandoh Kaori, Fukuda Hisato, Kita Masato, Okada Hidetaka, Tsuta Koji
Department of Pathology, Division of Diagnostic Pathology, Kansai Medical University, Osaka, Japan.
Department of Obstetrics and Gynecology, Kansai Medical University, Osaka, Japan.
Diagn Cytopathol. 2022 Oct;50(10):E285-E288. doi: 10.1002/dc.24997. Epub 2022 Jun 2.
Few cytological reports have described small-cell neuroendocrine carcinoma (SCNEC) in the female genital tract. In the present study, we describe a cytological case of SCNEC accompanied by adenocarcinoma, as well as high-grade squamous intraepithelial lesion (HSIL). A Japanese woman (42 years old) presented with abnormal genital bleeding. A conventional Papanicolaou smear revealed an inflammatory condition with three neoplastic components: SCNEC as irregular aggregates of neoplastic small round cells with nuclear molding and granular chromatin; adenocarcinoma as columnar cell clusters with peripherally located large nuclei, and HSIL as sheets or clusters of dysplastic basal-type squamous cells with irregular hyperchromatic nuclei. Accordingly, a cytodiagnosis of SCNEC with adenocarcinoma and HSIL was made. Owing to the rarity of cervical SCNEC, cytological diagnosis may be difficult. Due to its aggressive clinical behavior, the presence of an SCNEC component should be verified in any cytodiagnosis of adenocarcinoma or HSIL.
很少有细胞学报告描述女性生殖道中的小细胞神经内分泌癌（SCNEC）。在本研究中，我们描述了1例伴有腺癌以及高级别鳞状上皮内病变（HSIL）的SCNEC细胞学病例。一名日本女性（42岁）出现生殖器异常出血。传统巴氏涂片显示有炎症，伴有三种肿瘤成分：SCNEC表现为具有核异型性和颗粒状染色质的肿瘤性小圆形细胞不规则聚集；腺癌表现为柱状细胞簇，细胞核位于周边且较大；HSIL表现为发育异常的基底样鳞状细胞片或簇，细胞核不规则深染。因此，做出了SCNEC伴腺癌和HSIL的细胞诊断。由于宫颈SCNEC罕见，细胞学诊断可能困难。鉴于其侵袭性临床行为，在任何腺癌或HSIL的细胞诊断中都应核实是否存在SCNEC成分。
