Program in Medical and Population Genetics and the Cardiovascular Disease Initiative Broad Institute of MIT and Harvard Cambridge MA.
Cardiovascular Research Center Massachusetts General Hospital Boston MA.
J Am Heart Assoc. 2022 Jun 7;11(11):e024790. doi: 10.1161/JAHA.121.024790. Epub 2022 Jun 2.
Background Favorable cardiovascular health (CVH) in young adulthood has been associated with lower future cardiovascular risk. We determined whether CVH and its sex differences in young adults have changed from 2007 to 2018. Methods and Results We identified 10 206 individuals, aged 20 to 39 years, from the National Health Examination and Nutrition Survey data. CVH was assessed on the basis of the American Heart Association's Life's Simple 7 metrics (of 7). Changes in the mean number of ideal CVH components and the ideal proportion of individual components were calculated using linear regression analysis. Changes in sex difference trends were assessed with an interaction term between sex and calendar year. The mean (SD) age of the study population was 29.3 (5.8) years, and 5260 (51.5%) individuals were women. The mean (SD) ideal CVH component remained unchanged for both women (4.40 [1.22] to 4.48 [1.15]; =0.94) and men (3.97 [1.27] to 3.93 [1.24]; =0.87), with stable sex differences ( for interaction=0.94). Nonetheless, sex differences in blood pressure widened as ideal blood pressure decreased in men (54.0% to 46.9%; =0.03) but not in women ( for interaction <0.001). Concurrently, the proportion with ideal physical activity declined in women (57.3% to 49.4%; =0.04) but remained stable in men ( for interaction=0.03). Nonsmoking increased to a greater extent in women (64.1% to 70.5%; =0.05) than in men ( for interaction=0.01). Conclusions Sex disparities in CVH have persisted with exacerbated differences in blood pressure, physical activity, and smoking. These insights provide opportunities to promote equitable CVH.
年轻时心血管健康(CVH)良好与未来心血管风险较低有关。我们确定了年轻人的 CVH 及其性别差异是否从 2007 年到 2018 年发生了变化。
我们从国家健康检查和营养调查数据中确定了 10206 名年龄在 20 至 39 岁的个体。根据美国心脏协会的“生命简单 7 指标”(共 7 项)评估 CVH。使用线性回归分析计算理想 CVH 成分的平均数量和个别成分的理想比例的变化。使用性别与日历年份之间的交互项评估性别差异趋势的变化。研究人群的平均(SD)年龄为 29.3(5.8)岁,5260(51.5%)名个体为女性。女性(4.40[1.22]至 4.48[1.15];=0.94)和男性(3.97[1.27]至 3.93[1.24];=0.87)的理想 CVH 成分平均值保持不变,性别差异稳定(交互项=0.94)。尽管如此,随着男性理想血压的降低,男性血压的性别差异扩大(54.0%至 46.9%;=0.03),但女性没有(交互项<0.001)。同时,女性的理想体力活动比例下降(57.3%至 49.4%;=0.04),而男性保持稳定(交互项=0.03)。女性的不吸烟率增加到更大程度(64.1%至 70.5%;=0.05),而男性则没有(交互项=0.01)。
CVH 的性别差异仍然存在,血压、体力活动和吸烟方面的差异加剧。这些发现为促进公平的 CVH 提供了机会。