Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.
Department of Otolaryngology, Elsan Hospital, Paris, France.
Eur Arch Otorhinolaryngol. 2022 Dec;279(12):5741-5753. doi: 10.1007/s00405-022-07466-9. Epub 2022 Jun 2.
To investigate epidemiological, clinical and oncological outcomes of young patients with laryngeal cancer (LC).
PubMed, Scopus and Cochrane Library were searched by three researchers for studies investigating epidemiological, clinical and oncological outcomes of patients with age < 40 years old and LC. The following outcomes were investigated with PRISMA criteria: age; ethnicity; gender; tobacco/alcohol habits; anatomical, pathological, therapeutic and survival features. Authors performed a bias analysis of papers and provided recommendations for future studies.
Seventeen papers published between 1982 and 2021 met our inclusion criteria, accounting for 928 patients with age < 40 years (female/male ratio: 2:5). There were on average 54.2 and 45.8% of smokers and drinkers. The tumor location mainly consisted of glottis (70.1%), supraglottis (27.7%) and subglottis (2.2%). Radiation therapy was the main therapeutic strategy used in young adults with LC. The 2-year overall survival ranged from 50 to 100% and depended on tumor stage, treatment, and cohort features. Four studies reported better overall survival in young compared with old adults, while there were no significant differences in three studies. There was an important heterogeneity between studies regarding the inclusion/exclusion criteria, epidemiological, clinical, pathological and treatment.
It was suggested that young patients with LC had lower proportion of smokers and drinkers and better overall survival compared with older but both data of the current literature and heterogeneity between studies limit us to draw definitive conclusions.
研究年轻喉癌（LC）患者的流行病学、临床和肿瘤学结局。
三位研究人员通过 PubMed、Scopus 和 Cochrane Library 检索了调查年龄<40 岁且患有 LC 的患者的流行病学、临床和肿瘤学结局的研究。使用 PRISMA 标准调查了以下结局：年龄；种族；性别；烟草/酒精习惯；解剖、病理、治疗和生存特征。作者对论文进行了偏倚分析，并为未来的研究提供了建议。
1982 年至 2021 年间发表的 17 篇论文符合我们的纳入标准，共纳入 928 例年龄<40 岁的患者（女性/男性比例：2:5）。吸烟者和饮酒者的平均比例分别为 54.2%和 45.8%。肿瘤部位主要位于声门（70.1%）、声门上（27.7%）和声门下（2.2%）。放射治疗是年轻 LC 患者的主要治疗策略。2 年总生存率为 50%至 100%，取决于肿瘤分期、治疗和队列特征。四项研究报告年轻患者的总生存率优于老年患者，而三项研究无显著差异。关于纳入/排除标准、流行病学、临床、病理和治疗，研究之间存在重要的异质性。
年轻 LC 患者的吸烟者和饮酒者比例较低，总生存率较高，但当前文献的数据和研究之间的异质性限制了我们得出明确的结论。
