喉癌铜死亡亚型相关基因的分子特征、免疫相关性分析、WGCNA 分析和机器学习建模。
Molecular characterization, immunocorrelation analysis, WGCNA analysis and machine learning modeling of genes associated with copper death subtypes of laryngeal cancer.
机构信息
Department of Otolaryngology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China.
Department of Otolaryngology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
出版信息
Technol Health Care. 2024;32(6):4707-4725. doi: 10.3233/THC-240932.
BACKGROUND
Laryngeal cancer is a malignant tumor that originates from the mucous membrane of the larynx. Currently, the specific involvement mechanism of copper death in laryngeal cancer patients has not been deeply studied.
OBJECTIVE
This study aims to explore the molecular characteristics and clinical survival significance of copper death-related genes in laryngeal cancer.
METHODS
Relevant transcriptomes and clinical data were retrieved and downloaded from the GEO database. Differential expression genes related to laryngeal cancer and copper death were selected, and the immune function, clinical risk correlation, and survival prognosis were analyzed.
RESULTS
The differential analysis results showed that the differential expression genes related to laryngeal cancer and Cu-proptosis included SLC31A1 and ATP7B, and there was interaction between the immune cell groups in the differential genes of copper death in laryngeal cancer. Decreasing the expression of the gene ANXA5 or increasing the expression of the gene SERPINH1 can increase the susceptibility to laryngeal cancer.
CONCLUSION
Copper death-related genes can affect the survival prognosis of laryngeal cancer patients. Detection of changes in their expression can provide new diagnostic and treatment directions for the progression of early-stage laryngeal cancer.
背景
喉癌是一种起源于喉部黏膜的恶性肿瘤。目前，铜死亡在喉癌患者中具体的参与机制尚未深入研究。
目的
本研究旨在探讨铜死亡相关基因在喉癌中的分子特征和临床生存意义。
方法
从 GEO 数据库中检索并下载与喉癌和铜死亡相关的转录组和临床数据，筛选出与喉癌和铜死亡相关的差异表达基因，并分析其免疫功能、临床风险相关性和生存预后。
结果
差异分析结果显示，与喉癌和铜死亡相关的差异表达基因包括 SLC31A1 和 ATP7B，并且在喉癌铜死亡的差异基因中存在免疫细胞群之间的相互作用。降低基因 ANXA5 的表达或增加基因 SERPINH1 的表达均可增加患喉癌的易感性。
结论
铜死亡相关基因可影响喉癌患者的生存预后。检测其表达变化可为早期喉癌的进展提供新的诊断和治疗方向。
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