Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Material Science and Engineering, Shenzhen University, Shenzhen 518060, P.R. China.
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, P.R. China.
ACS Nano. 2022 Jun 28;16(6):9785-9798. doi: 10.1021/acsnano.2c03550. Epub 2022 Jun 2.
Developing effective intelligent nanotheranostics is highly desirable for cancer treatment but remains challenging. In this study, an acidic tumor microenvironment-activated organosilica nanosystem, namely AD-Cu-DOX-HA, is straightforwardly constructed, which is composed of aggregation-induced emission (AIE)-active photosensitizer, copper ion-engineered aminosilica, direct coordination polymer of doxorubicin (DOX), and targeting component hyaluronic acid (HA). AD-Cu-DOX-HA is able to accurately distinguish cancer cells over normal cells; meanwhile, it simultaneously exhibits selective accumulation and copper ion-mediated rapid disassembly and turn-on fluorescence in tumor tissue, consequently achieving efficient tumor diagnosis and tumor-growth inhibition through fluorescence imaging-navigated synergetic photodynamic therapy, copper ion-mediated chemodynamic therapy, and DOX-enabled chemotherapy. This work thus brings fresh insight into the exploration of versatile theranostics and presents a momentous advance for potential clinical cancer treatment.
开发有效的智能纳米诊疗剂对于癌症治疗非常重要，但仍然具有挑战性。在本研究中，构建了一种酸性肿瘤微环境激活的有机硅纳米系统，即 AD-Cu-DOX-HA，它由聚集诱导发射（AIE）活性光敏剂、铜离子工程化氨基硅、阿霉素（DOX）的直接配位聚合物和靶向成分透明质酸（HA）组成。AD-Cu-DOX-HA 能够准确区分癌细胞和正常细胞；同时，它在肿瘤组织中表现出选择性积累和铜离子介导的快速解组装和荧光开启，从而通过荧光成像导航的协同光动力疗法、铜离子介导的化学动力学疗法和 DOX 实现的化学疗法来有效抑制肿瘤生长。这项工作为多功能诊疗的探索带来了新的视角，并为癌症的潜在临床治疗带来了重大进展。
