Department of Dermatology, Saint-André Hospital, University Hospital of Bordeaux, Bordeaux, France.
FISARD, French Investigators for Skin Adverse Reactions to Drugs of the French Society of Dermatology, Paris, France.
Br J Dermatol. 2022 Oct;187(4):615-617. doi: 10.1111/bjd.21692. Epub 2022 Jul 25.
The two clinico-pathological patterns are 'Sweet-like syndrome' and 'Multiple COVID-Arm'. 'Sweet-like syndrome' presents clinically as erythematous and oedematous papules or plaques, sometimes developing vesiculation or bullae. Histology shows classical Sweet syndrome with a diffuse dermal neutrophilic infiltrate, or an infiltrate of histiocyte-like immature myeloid cells consistent with a histiocytoid Sweet syndrome. 'Multiple COVID-arm' is characterized by multiple large inflammatory plaques with histological analyses showing a perivascular and interstitial inflammatory infiltrate with eosinophils.
这两种临床病理类型分别是“类Sweet 综合征”和“多部位 COVID 相关皮疹”。“类Sweet 综合征”临床上表现为红斑性和水肿性丘疹或斑块，有时会出现水疱或大疱。组织学表现为经典的 Sweet 综合征，表现为弥漫性真皮中性粒细胞浸润，或组织细胞样未成熟髓样细胞浸润，符合组织细胞样 Sweet 综合征。“多部位 COVID 相关皮疹”的特征是多个大的炎症性斑块，组织学分析显示血管周围和间质炎症浸润伴有嗜酸性粒细胞。
