From the SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.
Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada.
J Pediatr Gastroenterol Nutr. 2022 Aug 1;75(2):116-119. doi: 10.1097/MPG.0000000000003500. Epub 2022 Jun 1.
Pediatric inflammatory bowel disease (IBD) is becoming increasingly common around the world, rapidly accelerating in regions undergoing rapid economic development. IBD is more common among those living in cities, and the association between the urban environment and IBD incidence is strongest in children. The "urban exposome" is defined as the totality of environmental exposures associated with urban living: air pollution, water contamination, green and blue space, nighttime light, noise, and availability of pre-processed and packaged foods. Investigation of the role of the urban exposome and IBD is in its infancy. Existing research has reached heterogeneous conclusions, and most studies have focused specifically on adult-onset disease and environmental exposures in isolation rather than the interaction between exposures. By better understanding the impact of the urban exposome on pediatric IBD, we can work to minimize these exposures and decrease the future burden of IBD in children.
儿科炎症性肠病（IBD）在全球范围内变得越来越普遍，在快速发展的经济地区迅速加速。IBD 在城市居民中更为常见，城市环境与 IBD 发病率之间的关联在儿童中最强。“城市暴露组”被定义为与城市生活相关的所有环境暴露：空气污染、水污染、绿色和蓝色空间、夜间灯光、噪音以及预加工和包装食品的供应。对城市暴露组与 IBD 之间关系的研究还处于起步阶段。现有研究得出了不一致的结论，而且大多数研究都专门针对成人发病和孤立的环境暴露，而不是暴露之间的相互作用。通过更好地了解城市暴露组对儿科 IBD 的影响，我们可以努力减少这些暴露，并降低儿童未来 IBD 的负担。
