IEEE Rev Biomed Eng. 2024;17:310-321. doi: 10.1109/RBME.2022.3179742. Epub 2024 Jan 12.
Radiofrequency ablation (RFA) combined with saline infusion into tissue is a promising technique to ablate larger tumours. Nevertheless, the application of saline-infused RFA remains at clinical trials due to the contradictory findings as a result of the inconsistencies in experimental procedures. These inconsistencies not only magnify the number of factors to consider during the treatment, but also obscure the understanding of the role of saline in enlarging the coagulation zone. Consequently, this can result in major complications, which includes unwanted thermal damages to adjacent tissues and also incomplete ablation of the tumour. This review aims to identify the key factors of saline responsible for enlarging the coagulation zone during saline-infused RFA, and provide a proper understanding on their effects that is supported with findings from computational studies to ensure a safe and reliable cancer treatment.
射频消融（RFA）联合盐水输注到组织中是一种有前途的消融较大肿瘤的技术。然而，由于实验程序的不一致性导致结果存在矛盾，盐水输注 RFA 的应用仍处于临床试验阶段。这些不一致性不仅增加了治疗过程中需要考虑的因素数量，而且还模糊了对盐水在扩大凝固区域中的作用的理解。因此，这可能导致严重的并发症，包括对相邻组织的不必要的热损伤以及肿瘤的不完全消融。本综述旨在确定盐水在盐水输注 RFA 中扩大凝固区域的关键因素，并提供对其影响的正确理解，这得到了计算研究结果的支持，以确保安全可靠的癌症治疗。
