Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, Republic of Korea.
Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Cardiovasc Intervent Radiol. 2019 Jun;42(6):886-892. doi: 10.1007/s00270-019-02178-w. Epub 2019 Feb 13.
To evaluate the efficacy of cisplatin-infused and normal saline-infused radiofrequency ablation (RFA) with internally cooled perfusion (ICP) electrode.
Using a 200 W generator, thirty ablation zones were created and divided into three groups of 10 each as follows: group A, RFA alone with 16 gauge monopolar internally cooled (IC) electrode; group B, cisplatin-infused RFA with 16 gauge ICP electrode; and group C, normal saline-infused RFA with 16 gauge ICP electrode. Radiofrequency was applied to the explanted bovine liver for 12 min. During RFA, cisplatin and normal saline were injected into tissue at a rate of 0.5 mL/min through the ICP electrode by injection pump. Dimensions of the ablation zone and technical parameters were compared between the three groups.
In the cisplatin-infused RFA group, the ablation zone size was significantly larger than that of the RFA-alone group but significantly smaller than normal saline-infused RFA group. The width of longitudinal section and volume were 3.39 ± 0.22 cm and 26.55 ± 4.62 cm in RFA-alone group, 3.88 ± 0.32 cm and 36.45 ± 5.46 cm in cisplatin-infused RFA group, and 4.52 ± 0.50 cm and 49.44 ± 7.55 cm in normal saline-infused RFA group, respectively (p < 0.05 between any two groups). The mean impedance in group A, B, and C were 60.0 ± 7.2, 50.3 ± 2.5, and 40.3 ± 4.0 Ω, respectively (p < 0.05 between any two groups).
Cisplatin-infused RFA with ICP electrode created the larger size of ablation zone than that of monopolar RFA with an IC electrode, but created the smaller size of ablation zone than that of normal saline-infused RFA.
评估顺铂输注和生理盐水输注联合内置冷却灌注（ICP）电极射频消融（RFA）的疗效。
使用 200 W 发生器，创建了 30 个消融区域，并将其分为三组，每组 10 个：A 组，单独使用 16 号单极内置冷却（IC）电极的 RFA；B 组，使用 16 号 ICP 电极的顺铂输注 RFA；C 组，使用 16 号 ICP 电极的生理盐水输注 RFA。将射频应用于离体牛肝 12 分钟。在 RFA 过程中，通过注射泵以 0.5 mL/min 的速度将顺铂和生理盐水注入组织。比较三组之间的消融区域尺寸和技术参数。
在顺铂输注 RFA 组，消融区域尺寸明显大于单独 RFA 组，但明显小于生理盐水输注 RFA 组。单独 RFA 组的纵向截面宽度和体积分别为 3.39±0.22 cm 和 26.55±4.62 cm，顺铂输注 RFA 组为 3.88±0.32 cm 和 36.45±5.46 cm，生理盐水输注 RFA 组为 4.52±0.50 cm 和 49.44±7.55 cm（任意两组之间 p<0.05）。A、B 和 C 组的平均阻抗分别为 60.0±7.2、50.3±2.5 和 40.3±4.0 Ω（任意两组之间 p<0.05）。
与内置冷却灌注电极的单极 RFA 相比，顺铂输注联合内置冷却灌注电极的 RFA 可产生更大的消融区域，但与生理盐水输注 RFA 相比，产生的消融区域较小。
