Department of Obstetrics and Gynecology, National Hospital Organization, Kasumigaura Medical Center, Tsuchiura, Japan.
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
J Obstet Gynaecol. 2022 Aug;42(6):2064-2068. doi: 10.1080/01443615.2022.2065906. Epub 2022 Jun 2.
Elevated serum levels of cancer antigen 125 (CA125) are known to occur in adenomyosis. However, the relationship between the severity of adenomyosis and serum CA125 levels has not yet been elucidated. The present study aimed to examine the correlation between the weight of adenomyosis and the serum CA125 level. This retrospective study, after applying exclusion criteria, investigated 308 patients who underwent conservative surgery for adenomyosis. Serum CA125 levels were measured before surgery and weights of surgically enucleated adenomyosis were measured in the operating room. Both serum CA125 and surgically enucleated adenomyosis weight showed log-normal distributions. Pearson's product-moment correlation coefficient for the logarithmically converted values was 0.617 (95% confidence interval, 0.54-0.68).The serum CA125 level correlated positively with the weight of adenomyosis. Although the qualitative characteristics and clinical significance of adenomyosis lesions remain unclear, it seems that the investigation of the relative relationship between the serum CA125 level and the size of the affected lesion is useful to observe one of the qualitative features of adenomyosis. Furthermore, the present study supports the use of postoperative serum CA125 levels as an important indicator for determining the therapeutic effects of conservative surgical treatment for adenomyosis and detecting early signs of recurrence. Impact Statement Elevated serum cancer antigen 125 (CA125) levels are known to occur in adenomyosis and are widely recognised as helpful in the diagnosis of adenomyosis. There is a positive correlation between the serum CA125 level and the weight of adenomyosis. The postoperative serum CA125 level is an important indicator for evaluating the extent of the affected lesion remaining after conservative surgical treatment for adenomyosis and also helpful for detecting early signs of recurrence. Further study is required to examine whether it is possible to clarify the qualitative characteristics of adenomyosis in each different case based on the CA125-producing ability of the lesion.
血清癌抗原 125（CA125）水平升高已知发生在子宫腺肌病中。然而，子宫腺肌病的严重程度与血清 CA125 水平之间的关系尚未阐明。本研究旨在检查子宫腺肌病的重量与血清 CA125 水平之间的相关性。本回顾性研究在应用排除标准后，调查了 308 例因子宫腺肌病接受保守手术的患者。手术前测量血清 CA125 水平，在手术室测量手术切除的子宫腺肌病的重量。血清 CA125 和手术切除的子宫腺肌病重量均呈对数正态分布。对数转换值的 Pearson 积矩相关系数为 0.617（95%置信区间，0.54-0.68）。血清 CA125 水平与子宫腺肌病的重量呈正相关。虽然子宫腺肌病病变的定性特征和临床意义尚不清楚，但似乎调查血清 CA125 水平与受累病变大小之间的相对关系有助于观察子宫腺肌病的定性特征之一。此外，本研究支持将术后血清 CA125 水平用作评估保守手术治疗子宫腺肌病后残留病变程度和检测早期复发迹象的重要指标。
影响陈述
已知血清癌抗原 125（CA125）水平升高发生在子宫腺肌病中，并且广泛认为有助于子宫腺肌病的诊断。血清 CA125 水平与子宫腺肌病的重量之间存在正相关。术后血清 CA125 水平是评估子宫腺肌病保守手术后残留病变程度的重要指标，也有助于检测早期复发迹象。需要进一步研究以检查是否可以根据病变的 CA125 产生能力来阐明每个不同病例中子宫腺肌病的定性特征。
