Inönü University, Medical Faculty, Department of Histology and Embryology.
Department of Medical Biochemistry, Faculty of Medicine, Inonu University, Turkey.
Tissue Cell. 2022 Aug;77:101824. doi: 10.1016/j.tice.2022.101824. Epub 2022 May 17.
Exposure to various organic compounds including several environmental pollutants and drugs can cause cellular damage through the generation of lipid peroxidation products. Carbon tetrachloride (CCl) is a potent toxic agent that causes peroxidative degeneration in many tissues. Dexpanthenol (Dxp) is a member of the B complex vitamins that exhibits antioxidant effects against lipid peroxidation products. This study was designed to evaluate the cardioprotective effect of Dxp against CCl-induced myocardial toxicity in rats. Administration of a single dose of CCl caused cardiotoxicity by the increase in lipid peroxidation and histopathological changes (cardiomyocytes degeneration, interstitial edema) in the myocardial tissue. Moreover, CCl caused a decrease in lactate dehydrogenase (LDH) and troponin-I immunoreactivities, while significantly increasing tumor necrosis factor-alpha (TNF-α) and caspase-3 immunoreactivities. On the other hand, administration of Dxp improved biochemical, histopathological, and immunohistochemical parameters compared to the CCl treated group. Overall, this study suggests that Dxp is effective in inhibiting CCl-induced lipid peroxidation, and that administration of Dxp may help prevent CCl related inflammation, necrosis, and apoptosis on the cardiac tissue.
暴露于各种有机化合物，包括多种环境污染物和药物，可通过生成脂质过氧化产物而导致细胞损伤。四氯化碳（CCl）是一种有效的有毒物质，可引起许多组织的过氧化变性。泛醇（Dxp）是 B 族维生素的成员，具有对抗脂质过氧化产物的抗氧化作用。本研究旨在评估 Dxp 对 CCl 诱导的大鼠心肌毒性的心脏保护作用。单次给予 CCl 可通过增加脂质过氧化和心肌组织的组织病理学变化（心肌细胞变性、间质水肿）引起心脏毒性。此外，CCl 导致乳酸脱氢酶（LDH）和肌钙蛋白-I 免疫反应性降低，而肿瘤坏死因子-α（TNF-α）和半胱天冬酶-3 免疫反应性显著增加。另一方面，与 CCl 处理组相比，Dxp 的给药改善了生化、组织病理学和免疫组织化学参数。总体而言，这项研究表明 Dxp 能有效抑制 CCl 诱导的脂质过氧化，并且 Dxp 的给药可能有助于预防 CCl 相关的炎症、坏死和心脏组织的细胞凋亡。
