State Key Laboratory of Pollution Control and Resource Reuse, Jiangsu Key Laboratory of Vehicle Emissions Control, School of the Environment, Nanjing University, Nanjing 210023, People's Republic of China.
Jiangsu SEP Analytical Services Co., Ltd, Nanjing 210033, People's Republic of China.
Sci Total Environ. 2022 Sep 15;839:156366. doi: 10.1016/j.scitotenv.2022.156366. Epub 2022 May 30.
To assess the health risk of nickel (Ni) in contaminated soils, studies rarely evaluated Ni bioavailability in the gastrointestinal (GI) tract, limiting the accurate regulation of contaminated sites. Here, for 15 soil samples contaminated by Ni-electroplating, Ni oral relative bioavailability (RBA, relative to NiSO) was measured using a mouse urinary excretion bioassay. Nickel-RBA varied from 7.89% to 33.8% at an average of 19.1 ± 18.6%. The variation was not explained well by variation in soil properties including Ni speciation and co-contamination of other metals, which showed weak correlation with Ni-BRA (R < 0.36). In comparison, the Ni-RBA variation was explained well by the variation of soil-Ni solubility in simulated human gastric or gastrointestinal fluids, i.e., Ni bioaccessibility. Determined using the gastric (GP) and intestinal phases (IP) of solubility bioaccessibility research consortium (SBRC), physiologically based extraction test methods (PBET), and unified BARGE method (UBM), Ni bioaccessibility explained 54-71% variation of the Ni-RBA, suggesting that Ni oral bioavailability was predominantly controlled by Ni solubility in the GI tract. The results highlight the suitability of using simple, fast, and cost-effective bioaccessbility assays to predict site-specific Ni oral bioavailability.
为了评估污染土壤中镍（Ni）的健康风险，研究很少评估胃肠道（GI）中 Ni 的生物可利用性，限制了对污染场地的准确监管。在这里，对于 15 个受 Ni 电镀污染的土壤样本，使用小鼠尿液排泄生物测定法测量了 Ni 的口服相对生物利用度（RBA，相对于 NiSO）。Ni-RBA 的范围为 7.89%至 33.8%，平均为 19.1±18.6%。土壤特性的变化（包括 Ni 形态和其他金属的共污染）无法很好地解释 Ni-RBA 的变化，与 Ni-RBA 的相关性较弱（R<0.36）。相比之下，Ni-RBA 的变化很好地解释了模拟人类胃或胃肠道液中土壤-Ni 溶解度的变化，即 Ni 的生物可及性。通过胃（GP）和肠相（IP）溶解度生物可及性研究联盟（SBRC）、基于生理的提取测试方法（PBET）和统一 BARGE 方法（UBM）来确定，Ni 生物可及性解释了 Ni-RBA 变化的 54-71%，表明 Ni 口服生物利用度主要受 GI 道中 Ni 溶解度的控制。研究结果强调了使用简单、快速且具有成本效益的生物可利用性测定法来预测特定地点 Ni 口服生物利用度的适宜性。
