Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
J Glaucoma. 2022 Aug 1;31(8):682-688. doi: 10.1097/IJG.0000000000002057. Epub 2022 Jun 2.
A Kaplan-Meier survival curve analysis showed no significant differences in success rates between uveitic glaucoma (UG) and primary open angle glaucoma (POAG) 120 months after modified 360-degree suture trabeculotomy, which was effective for both groups in the long term.
The aim of this study was to examine the outcomes of modified 360-degree suture trabeculotomy in patients with UG as compared with those with POAG.
This was a retrospective, nonrandomized, and comparative case series study. Modified 360-degree trabeculotomy using a 5-0 nylon suture (S-LOT) was performed on 51 eyes of 51 patients (54.4±13.4 y) with UG between October 2005 and January 2012 at Hokkaido University Hospital. Age-matched patients with POAG who underwent S-LOT during the same period were enrolled as controls. Written informed consent was obtained from all patients enrolled in the present study. Surgical success was defined as an intraocular pressure (IOP) <18 mm Hg with similar or lower doses of antiglaucoma medications. Kaplan-Meier survival curves of surgical failure were analyzed and compared between UG and POAG.
The mean follow-up periods (±SD) for UG and POAG were 104.8±44.0 and 98.1±36.3 months ( P =0.23), respectively. Mean preoperative IOP in UG and POAG were 34.9±11.0 and 25.3±9.4 mm Hg ( P <0.001), respectively. After surgery, mean IOP in UG and POAG decreased to 12.0±4.1 and 13.8±3.2 mm Hg, respectively, at 60 months, and 12.1±5.6 and 12.4±1.8 mm Hg ( P =0.86), respectively, at 120 months. The Kaplan-Meier survival curve analysis showed no significant differences in success rates between UG and POAG at the end of the follow-up (Log-rank test, P =0.13). Success rates in UG and POAG were 70.0 and 62.5% at 60 months, and 67.5 and 41.2% at 120 months, respectively.
These results suggest that S-LOT is effective for UG and POAG alike.
卡普兰-迈耶生存曲线分析显示，改良 360 度缝线小梁切开术后 120 个月，葡萄膜炎性青光眼（UG）和原发性开角型青光眼（POAG）的成功率无显著差异，长期来看，两组均有效。
本研究旨在比较改良 360 度缝线小梁切开术治疗葡萄膜炎性青光眼和原发性开角型青光眼的疗效。
这是一项回顾性、非随机、对照病例系列研究。2005 年 10 月至 2012 年 1 月，北海道大学医院对 51 例（51 只眼）葡萄膜炎性青光眼患者（54.4±13.4 岁）采用 5-0 尼龙缝线（S-LOT）行改良 360 度缝线小梁切开术。同期年龄匹配的原发性开角型青光眼患者行 S-LOT 作为对照组。所有纳入本研究的患者均签署书面知情同意书。手术成功定义为眼压（IOP）<18mmHg，抗青光眼药物用量相似或更低。对葡萄膜炎性青光眼和原发性开角型青光眼的手术失败进行 Kaplan-Meier 生存曲线分析，并进行比较。
葡萄膜炎性青光眼和原发性开角型青光眼的平均随访时间（±SD）分别为 104.8±44.0 个月和 98.1±36.3 个月（P=0.23）。葡萄膜炎性青光眼和原发性开角型青光眼术前平均 IOP 分别为 34.9±11.0mmHg 和 25.3±9.4mmHg（P<0.001）。术后 60 个月，葡萄膜炎性青光眼和原发性开角型青光眼的平均 IOP 分别降至 12.0±4.1mmHg 和 13.8±3.2mmHg，术后 120 个月分别降至 12.1±5.6mmHg 和 12.4±1.8mmHg（P=0.86）。Kaplan-Meier 生存曲线分析显示，随访结束时葡萄膜炎性青光眼和原发性开角型青光眼的成功率无显著差异（对数秩检验，P=0.13）。60 个月时，葡萄膜炎性青光眼和原发性开角型青光眼的成功率分别为 70.0%和 62.5%，120 个月时分别为 67.5%和 41.2%。
这些结果表明，S-LOT 对葡萄膜炎性青光眼和原发性开角型青光眼均有效。
