Yu Shiwen, Wang Yiran, Fan Yali, Ma Ruimin, Wang Yuanying, Ye Qiao
Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital Capital Medical University, Beijing, China.
Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital Capital Medical University, Beijing, China
Occup Environ Med. 2022 Jun 2. doi: 10.1136/oemed-2021-108095.
This study aims to explore the prevalence and clinical features of pulmonary hypertension (PH) in patients with progressive massive fibrosis (PMF) and its correlation with large opacities on CT scans.
This retrospective study collected 235 patients with PMF, and 199 were eligible for analysis. The probability of PH development was estimated based on tricuspid regurgitation velocity measured by echocardiogram. The size and the location of large opacities on chest CT were recorded. Potential risk factors for PH secondary to PMF were analysed using regression analysis.
The prevalence of a high or intermediate probability of PH was 39.7% in patients with PMF. Type C of large opacities (OR 6.99, 95% CI 2.34 to 23.00, p<0.001) and central type of the large opacities (OR 8.12, 95% CI 2.89 to 24.71, p<0.001) were identified as the risk factors for PH secondary to PMF. Over a median follow-up of 32.8 months, the survival rate was 73.3% in the PH group, significantly lower than that in the non-PH group (96.6%, p<0.001).
Over one-third of patients with PMF developed PH. The increased size and the central distribution of large opacities were identified as the risk factors.
本研究旨在探讨进行性大块纤维化（PMF）患者肺动脉高压（PH）的患病率、临床特征及其与CT扫描上大阴影的相关性。
这项回顾性研究收集了235例PMF患者，其中199例符合分析条件。根据超声心动图测量的三尖瓣反流速度估计PH发生的概率。记录胸部CT上大阴影的大小和位置。采用回归分析方法分析PMF继发PH的潜在危险因素。
PMF患者中PH高概率或中概率的患病率为39.7%。大阴影C型（比值比6.99，95%可信区间2.34至23.00，p<0.001）和大阴影中央型（比值比8.12，95%可信区间2.89至24.71，p<0.001）被确定为PMF继发PH的危险因素。在中位随访32.8个月期间，PH组的生存率为73.3%，显著低于非PH组（96.6%，p<0.001）。
超过三分之一的PMF患者发生了PH。大阴影大小增加和中央分布被确定为危险因素。
