Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China.
BMJ Open. 2023 Apr 3;13(4):e068628. doi: 10.1136/bmjopen-2022-068628.
To describe the prevalence, clinical features and potential risk factors of pneumoconiosis in combination with connective tissue disease (CTD) or positive autoantibodies.
Cross-sectional study.
A retrospective study of adults recruited in China between December 2016 and November 2021.
A total of 931 patients with pneumoconiosis at Beijing Chao-Yang Hospital were enrolled in this study; of these, 580 patients were included in the final analysis.
Pneumoconiosis combined with CTD or positive autoantibodies was a major adverse outcome.
In total, 13.8% (80/580) of the patients had combined pneumoconiosis with CTD, among whom the prevalence of CTD was 18.3% (46/251) in asbestosis and 11.4% (34/298) in silicosis/coal mine workers' pneumoconiosis. In comparison to the general Chinese adult population, the relative risk of various CTD in pneumoconiosis, including rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, primary Sjögren's syndrome, idiopathic inflammatory myopathy and antineutrophil cytoplasmic antibodies-associated vasculitis, were 11.85, 12.12, 127.40, 4.23, 9.94 and 644.66, respectively. Multivariate analysis revealed that female sex (OR 2.55, 95% CI 1.56 to 4.17) and a later stage of pneumoconiosis (OR 2.04, 95% CI 1.24 to 3.34) were the independent risk factors for CTD in patients with pneumoconiosis (all p<0.050).
CTD is highly prevalent in patients with pneumoconiosis, especially in patients of asbestosis, and silicosis/coal mine workers' pneumoconiosis. Female sex and later stages of pneumoconiosis are associated with an increased risk of combined with CTD.
描述伴有结缔组织病（CTD）或阳性自身抗体的尘肺病的患病率、临床特征和潜在危险因素。
横断面研究。
一项在中国招募的成人回顾性研究，时间为 2016 年 12 月至 2021 年 11 月。
共纳入北京朝阳医院 931 例尘肺病患者，其中 580 例纳入最终分析。
尘肺病合并 CTD 或阳性自身抗体是一个主要的不良结局。
共有 13.8%（80/580）的患者合并有尘肺病和 CTD，其中石棉肺 CTD 的患病率为 18.3%（46/251），矽肺/煤矿工人尘肺为 11.4%（34/298）。与普通中国成年人相比，尘肺病中各种 CTD 的相对风险，包括类风湿关节炎、系统性红斑狼疮、系统性硬化症、原发性干燥综合征、特发性炎性肌病和抗中性粒细胞胞质抗体相关性血管炎，分别为 11.85、12.12、127.40、4.23、9.94 和 644.66。多因素分析显示，女性（OR 2.55，95%CI 1.564.17）和尘肺病晚期（OR 2.04，95%CI 1.243.34）是尘肺病患者发生 CTD 的独立危险因素（均 P<0.050）。
CTD 在尘肺病患者中患病率较高，尤其是石棉肺和矽肺/煤矿工人尘肺患者。女性和尘肺病晚期与合并 CTD 的风险增加相关。
