Gumbart C H, Sorensen S H, Bickers J N
Am J Med Sci. 1987 Feb;293(2):90-3. doi: 10.1097/00000441-198702000-00004.
Chemotherapy-induced nausea and vomiting cause morbidity and poor compliance among patients receiving intensive cancer chemotherapy. High-dose antiemetic regimens, while effective, add significantly to the cost of treatment. This study compares the efficacy and cost of high-dose metoclopramide with a combination of phenobarbital and droperidol. All patients treated were naive to prior chemotherapy, and all patients received treatment regimens containing cisplatinum. Both antiemetic regimens proved equally efficacious in suppressing emesis, but the phenobarbital/droperidol combination achieved a 100-fold decrease in cost.
化疗引起的恶心和呕吐会导致接受强化癌症化疗的患者出现发病情况且依从性较差。高剂量止吐方案虽然有效，但会显著增加治疗成本。本研究比较了高剂量甲氧氯普胺与苯巴比妥和氟哌利多联合使用的疗效和成本。所有接受治疗的患者之前均未接受过化疗，且所有患者均接受了含顺铂的治疗方案。两种止吐方案在抑制呕吐方面均证明同样有效，但苯巴比妥/氟哌利多联合使用使成本降低了100倍。
