Donovitz G S, O'Quinn A G, Smith M L
Gynecol Oncol. 1984 Jul;18(3):320-5. doi: 10.1016/0090-8258(84)90043-x.
The nausea and vomiting associated with cisplatin chemotherapy make care of the patient more difficult for nurses and physicians, can cause severe metabolic and pathologic sequelae, and preclude further courses of chemotherapy. Current reports suggest that the two most efficacious agents for antiemetic prophylaxis are metoclopramide and corticosteroids. These two agents in combination with droperidol have been compared in a randomized controlled prospective fashion. Patients had less nausea and vomiting on the steroidal regimen than the nonsteroidal regimen (P less than 0.05), and the duration of nausea and vomiting was significantly less on the steroidal regimen (P less than 0.05). Patients expressed a preference for the steroidal regimen over the nonsteroidal one and the steroidal regimen retained its antiemetic effectiveness through repeated courses of chemotherapy. The results of the study suggest that corticosteroids and droperidol are superior antiemetic agents for cisplatin-induced nausea and vomiting.
与顺铂化疗相关的恶心和呕吐，给护士和医生护理患者带来了更大困难，可导致严重的代谢和病理后遗症，并使进一步的化疗疗程无法进行。目前的报告表明，预防呕吐最有效的两种药物是甲氧氯普胺和皮质类固醇。已采用随机对照前瞻性方式对这两种药物与氟哌利多联合使用进行了比较。使用类固醇方案的患者比使用非类固醇方案的患者恶心和呕吐更少（P<0.05），且使用类固醇方案时恶心和呕吐的持续时间明显更短（P<0.05）。患者表示更喜欢类固醇方案而非非类固醇方案，并且类固醇方案在重复化疗疗程中仍保持其止吐效果。该研究结果表明，皮质类固醇和氟哌利多是治疗顺铂引起的恶心和呕吐的更优止吐药物。
