Kozeny G A, Hurley R M, Vertuno L L, Bansal V K, Zeller W P, Hano J E
Am J Nephrol. 1986;6(6):476-81. doi: 10.1159/000167258.
An 8-week-old infant with hypertension, hyperkalemia, and hyperchloremic acidosis, presumably due to chloride shunt type of distal renal tubular acidosis, is described. The patient's renin-aldosterone axis was intact. The infant was also found to have an obstructed solitary kidney. Despite correction of the obstruction and improvement in the glomerular filtration rate accompanied by normal development, hyperkalemia and renal tubular acidosis persisted. The defect was still demonstrable 9 months following relief of the obstruction. We conclude that neonatal obstructive uropathy can result in renal tubular acidosis of the chloride shunt type. The reversibility of this defect is, as yet, unknown.
本文描述了一名8周大的婴儿，患有高血压、高钾血症和高氯性酸中毒，推测病因是远端肾小管酸中毒的氯化物分流型。该患者的肾素-醛固酮轴完整。还发现该婴儿有一个孤立肾梗阻。尽管梗阻得到纠正，肾小球滤过率提高，且发育正常，但高钾血症和肾小管酸中毒仍持续存在。梗阻解除9个月后，该缺陷仍然存在。我们得出结论，新生儿梗阻性尿路病可导致氯化物分流型肾小管酸中毒。目前尚不清楚这种缺陷是否具有可逆性。
