Faculty of Physical Education & Sport Sciences, Department of Sport Physiology, University of Isfahan, Azadi Sq, HezarJerib Ave, P.O. Box, Isfahan, 81799-54359, Iran.
Department of Physiology, School of Medicine, University of Isfahan Medical Sciences, Isfahan, Iran.
Neurotox Res. 2022 Aug;40(4):1115-1124. doi: 10.1007/s12640-022-00527-1. Epub 2022 Jun 3.
The natural aging process as well as many age-related diseases is associated with impaired metabolic adaptation and declined ability to cope with stress. As major causes of disability and morbidity during the aging process, brain disorders, including psychiatric and neurodegenerative disorders, are likely to increase across the globe in the future decades. This narrative review investigates the link among exercise and brain disorders, aging, and inflammatory biomarkers, along with the function of brain-derived neurotrophic factor. For this study, related manuscript from all databases, Google scholar, Scopus, PubMed, and ISI were assessed. Also, in the search process, the keywords of exercise, neurodegeneration, neurotrophin, mitochondrial dysfunction, and aging were used. Mitochondrial abnormality increases neuronal abnormality and brain disease during the aging process. Stress and inflammatory factors caused by lifestyle and aging also increase brain disorders. Evidences suggest that exercise, as a noninvasive treatment strategy, has antioxidant effects and can reduce neuronal lesions. Brain-derived neurotrophic factor expression following the exercise can reduce brain symptoms; however, careful consideration should be given to a number of factors affecting the results.
自然衰老过程以及许多与年龄相关的疾病都与代谢适应能力受损和应对压力的能力下降有关。作为衰老过程中导致残疾和发病的主要原因，包括精神和神经退行性疾病在内的脑紊乱在未来几十年内可能在全球范围内增加。本综述探讨了运动与脑紊乱、衰老和炎症生物标志物之间的联系，以及脑源性神经营养因子的作用。为此，评估了来自所有数据库、Google Scholar、Scopus、PubMed 和 ISI 的相关手稿。此外，在搜索过程中，使用了运动、神经退行性变、神经营养因子、线粒体功能障碍和衰老等关键词。线粒体异常在衰老过程中增加神经元异常和脑疾病。生活方式和衰老引起的应激和炎症因子也会增加脑疾病。有证据表明，运动作为一种非侵入性治疗策略，具有抗氧化作用，可以减少神经元损伤。运动后脑源性神经营养因子的表达可以减轻脑症状；然而，应该仔细考虑影响结果的许多因素。
