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年龄和性别影响脱水 Wistar 大鼠脂代谢的反应。

Age and sex influence the response in lipid metabolism of dehydrated Wistar rats.

机构信息

Physiology Department, Ribeirao Preto Medicine School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, 14049-900, Brazil.

Department of Physiological Science, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.

出版信息

Sci Rep. 2022 Jun 2;12(1):9164. doi: 10.1038/s41598-022-11587-w.

DOI:10.1038/s41598-022-11587-w
PMID:35655069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9163080/
Abstract

Aging is associated a decrease in thirst sensation, which makes old people more susceptible to dehydration. Dehydration produces energy metabolism alterations. Our objective was to determinate the effect of water deprivation (WD) in the lipid metabolism of old male and female rats. Here we show that in the state of WD, aging and sex alters retroperitoneal white adipose tissue (R-WAT) weight of rats, WD old female rats had more lipolysis products than old male rats, a sexual dimorphism in the hormonal response related with metabolism of the adipose tissue of old rats during WD, the expression of P-para mRNA in R-WAT did not present any alteration in animals submitted to WD, the expression of Aqp7 mRNA in R-WAT is altered by WD, age, and sex. Also, WD stimulated an increase in the plasma concentration of oxytocin and the expression of mRNA of the oxytocin receptors in R-WAT.

摘要

衰老是与口渴感下降相关的，这使得老年人更容易脱水。脱水会导致能量代谢改变。我们的目的是确定水剥夺（WD）对老年雄性和雌性大鼠脂质代谢的影响。在这里，我们表明在 WD 状态下，衰老和性别改变了老年雄性和雌性大鼠的腹膜后白色脂肪组织（R-WAT）重量，WD 老年雌性大鼠比老年雄性大鼠有更多的脂肪分解产物，这是 WD 期间老年大鼠脂肪组织代谢相关的激素反应的性别二态性，在接受 WD 的动物中，R-WAT 中 P-para mRNA 的表达没有任何改变，R-WAT 中 Aqp7 mRNA 的表达被 WD、年龄和性别改变。此外，WD 刺激了血浆中催产素浓度的增加和 R-WAT 中催产素受体 mRNA 的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/61426deaaaf3/41598_2022_11587_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/16d46063f176/41598_2022_11587_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/238aa9b2ea9b/41598_2022_11587_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/5f6853f7b34f/41598_2022_11587_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/c572ead42d2d/41598_2022_11587_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/088c8b5023bc/41598_2022_11587_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/cdbfe18d442c/41598_2022_11587_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/54259b70864b/41598_2022_11587_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/61426deaaaf3/41598_2022_11587_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/16d46063f176/41598_2022_11587_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/238aa9b2ea9b/41598_2022_11587_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/5f6853f7b34f/41598_2022_11587_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/c572ead42d2d/41598_2022_11587_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/088c8b5023bc/41598_2022_11587_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/cdbfe18d442c/41598_2022_11587_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/54259b70864b/41598_2022_11587_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96ac/9163080/61426deaaaf3/41598_2022_11587_Fig8_HTML.jpg

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