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感染 SARS-CoV-2 三个月后的抗体反应。

Antibody response three months after SARS-CoV-2 infection.

机构信息

Department of Medical Services and Techniques, Toros Unıversity, Mersin, Turkey.

Tarsus State Hospital, Infectious Diseases, and Clinical Microbiology, Mersin, Turkey.

出版信息

J Med Virol. 2022 Oct;94(10):4712-4718. doi: 10.1002/jmv.27909. Epub 2022 Jun 10.

Abstract

The coronavirus disease-19 (COVID-19) pandemic became the greatest public health challenge globally. In our study, it was aimed to determine the antibody levels in the third month after the COVID-19 infection and the symptoms that continued until the third month from the onset of the infection. One hundred people who applied to Tarsus State Hospital with the suspicion of COVID-19 and were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by real-time reverse transcriptase-polymerase chain reaction were included. We collected serum samples from individuals, who were 3 months postinfection, and tested them in anti-SARS-CoV-2 Quanti-Vac ELISA IgG kit coated with recombinant S1 antigen for testing SARS-CoV-2 antibodies. Antibody levels were found to be higher in those aged ≥55 years, nonsmokers, those with comorbidities, and those who were hospitalized. The four most common symptoms that individuals initially encounter; are weakness, muscle and joint pain, loss of taste and smell, and cough. In 3 months after COVID-19 infection, the most common four symptoms are; muscle and joint pain, insomnia, fatigue, and other problems were determined. In conclusion; more research is needed to determine threshold levels of serum antibodies that could prevent reinfection of SARS-CoV-2.

摘要

新型冠状病毒病-19(COVID-19)大流行成为全球最大的公共卫生挑战。在我们的研究中,旨在确定 COVID-19 感染后第三个月的抗体水平以及从感染开始到第三个月仍持续存在的症状。100 名因怀疑感染 COVID-19 而到塔尔苏斯州立医院就诊且实时逆转录-聚合酶链反应检测严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)呈阳性的人被纳入研究。我们从感染后 3 个月的个体中采集血清样本,并在涂有重组 S1 抗原的抗 SARS-CoV-2 Quanti-Vac ELISA IgG 试剂盒中检测 SARS-CoV-2 抗体。结果发现,年龄≥55 岁、不吸烟、合并症和住院的个体抗体水平更高。个体最初遇到的四种最常见的症状是:乏力、肌肉和关节疼痛、味觉和嗅觉丧失以及咳嗽。在 COVID-19 感染后 3 个月,确定了四种最常见的症状是:肌肉和关节疼痛、失眠、疲劳和其他问题。总之,需要更多的研究来确定能够预防 SARS-CoV-2 再感染的血清抗体阈值水平。

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