Eh Dam V Sha Kri, Mohamad Nasibah, Muhamad Izyan Rifhana, Abdul Kadir Saeed Al Duais Saleh, Wan Abdul Rahman Wan Faiziah, Hussain Faezahtul Arbaeyah, Husin Azlan, Mat Lazim Norhafiza
Department of Otorhinolaryngology-Head & Neck Surgery, School of Medical Sciences, University Sains Malaysia Health Campus, 16150 Kota Bharu, Kelantan, Malaysia.
Department of Radiology, School of Medical Sciences, University Sains Malaysia, Health Campus, 16150 Kota Bharu, Kelantan, Malaysia.
Iran J Otorhinolaryngol. 2022 May;34(122):205-211. doi: 10.22038/IJORL.2022.62088.3133.
Nasopharyngeal carcinoma (NPC) is a nasopharyngeal epithelial neoplasm that has distinct aetiological, epidemiological and biological characteristics compared to other head and neck malignancies. Patients usually present late due to non-specific symptoms and deep location of the tumour in the nasopharynx.
We would like to highlight a case of advanced NPC presenting with generalised lymphadenopathy, without the presence of an obvious nasopharyngeal mass that masqueraded as lymphoma in the initial stage.
NPC may share clinical features with other sinonasal pathologies or other malignant lymphoproliferative disorders that lead to a delay in diagnosis. NPC should be one of the differential diagnoses for any cases presenting with cervical lymphadenopathy, especially in adult male patients originating from East or Southeast Asia. Early diagnosis and treatment are crucial because early-stage NPC has an excellent chemoradiotherapy response and high survival rate.
鼻咽癌（NPC）是一种鼻咽上皮性肿瘤，与其他头颈恶性肿瘤相比，具有独特的病因、流行病学和生物学特征。由于症状不具特异性且肿瘤位于鼻咽深部，患者通常就诊较晚。
我们想强调一例晚期鼻咽癌病例，该病例表现为全身淋巴结肿大，起初并无明显的鼻咽肿物，曾被误诊为淋巴瘤。
鼻咽癌可能与其他鼻窦疾病或其他恶性淋巴增殖性疾病具有共同的临床特征，从而导致诊断延迟。对于任何出现颈部淋巴结肿大的病例，尤其是来自东亚或东南亚的成年男性患者，鼻咽癌都应作为鉴别诊断之一。早期诊断和治疗至关重要，因为早期鼻咽癌对放化疗反应良好且生存率高。
