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透明质酸填充剂注射后迟发性结节:病例系列

Delayed Onset Nodules After Hyaluronic Acid Fillers: A Case Series.

作者信息

Dua Aman, Bhardwaj Bhawna

机构信息

A. K. Clinics, Ludhiana, Punjab, India.

A. K. Clinics, Delhi, India.

出版信息

J Cutan Aesthet Surg. 2022 Jan-Mar;15(1):91-94. doi: 10.4103/JCAS.JCAS_200_20.

DOI:10.4103/JCAS.JCAS_200_20
PMID:35655648
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9153319/
Abstract

Non-surgical techniques with hyaluronic acid fillers to rejuvenate face are very popular treatment due to ease of administration and achievement of faster improvement. Although they are considered to be safe procedures, few rare adverse effects have been reported in literatures. The number of these cosmetic procedures being performed is increasing every year. Simultaneously, the rate of filler complications has also increased. This case series presents three clinical cases of delayed onset nodules after hyaluronic acid fillers after 1-5 months post-procedure. Juvederm Volift was used in all the mentioned patients. Granulomatous reactions can occur with any of the hyaluronic acid fillers. These are generally localized immunological reactions. An awareness about these rare side effects helps us in the assessment and ensurance of accurate diagnosis and treatment.

摘要

使用透明质酸填充剂进行面部年轻化的非手术技术因易于操作且能更快改善效果而成为非常受欢迎的治疗方法。尽管它们被认为是安全的手术,但文献中报道了一些罕见的不良反应。每年进行的这些美容手术数量都在增加。同时,填充剂并发症的发生率也有所上升。本病例系列展示了3例在使用透明质酸填充剂后1至5个月出现延迟性结节的临床病例。所有提及的患者均使用了乔雅登极致。任何一种透明质酸填充剂都可能发生肉芽肿反应。这些通常是局部免疫反应。了解这些罕见的副作用有助于我们进行评估并确保准确的诊断和治疗。

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Cureus. 2023 Apr 29;15(4):e38286. doi: 10.7759/cureus.38286. eCollection 2023 Apr.

本文引用的文献

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Delayed-Onset Nodules to Differentially Crosslinked Hyaluronic Acids: Comparative Incidence and Risk Assessment.延迟出现的结节对差异化交联透明质酸的影响:比较发生率和风险评估。
Dermatol Surg. 2019 Aug;45(8):1085-1094. doi: 10.1097/DSS.0000000000001814.
2
Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers.透明质酸真皮填充剂的迟发性炎症反应。
Plast Reconstr Surg Glob Open. 2017 Dec 22;5(12):e1532. doi: 10.1097/GOX.0000000000001532. eCollection 2017 Dec.
3
Global Aesthetics Consensus: Avoidance and Management of Complications from Hyaluronic Acid Fillers-Evidence- and Opinion-Based Review and Consensus Recommendations.全球美学共识:透明质酸填充剂并发症的预防与处理——基于证据和观点的综述及共识建议
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The Hyaluronic Acid Fillers: Current Understanding of the Tissue Device Interface.透明质酸填充剂:对组织-器械界面的当前认识
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Delayed-onset nodules secondary to a smooth cohesive 20 mg/mL hyaluronic acid filler: cause and management.由20毫克/毫升平滑粘性透明质酸填充剂引起的迟发性结节:病因及处理
Dermatol Surg. 2015 Aug;41(8):929-39. doi: 10.1097/DSS.0000000000000418.
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Dermal fillers in aesthetics: an overview of adverse events and treatment approaches.美容领域中的真皮填充剂:不良事件及治疗方法概述
Plast Surg Nurs. 2015 Jan-Mar;35(1):13-32. doi: 10.1097/PSN.0000000000000087.
8
Dermal fillers in aesthetics: an overview of adverse events and treatment approaches.美容用皮肤填充剂:不良事件及处理方法概述。
Clin Cosmet Investig Dermatol. 2013 Dec 12;6:295-316. doi: 10.2147/CCID.S50546.
9
Complications from toxins and fillers in the dermatology clinic: recognition, prevention, and treatment.皮肤科诊所中由毒素和填充剂引起的并发症:识别、预防与治疗。
Facial Plast Surg Clin North Am. 2013 Nov;21(4):663-73. doi: 10.1016/j.fsc.2013.07.008.
10
Pseudocystic encapsulation: a late noninflammatory complication of hyaluronic acid filler injections.假性囊肿性包裹:透明质酸填充剂注射的一种晚期非炎性并发症。
Dermatol Surg. 2013 Nov;39(11):1726-8. doi: 10.1111/dsu.12316. Epub 2013 Oct 1.