Ross R, Harker L
Adv Exp Med Biol. 1978;102:135-41. doi: 10.1007/978-1-4757-1217-9_8.
A factor derived from platelets stimulates the proliferation of smooth muscle cells in culture, and is likely important in stimulating smooth muscle proliferative lesions of atherogenesis in vivo. The platelet factor is produced during platelet aggregation when serum is made from whole blood. In vitro, smooth muscle cells are potent aggregating agents for platelets, while endothelial cells can inhibit this aggregating effect. Better understanding of the interactions of platelets, smooth muscle cells, and endothelium would facilitate developing effective means of intervening in or preventing the smooth muscle proliferative lesions of atherosclerosis.
一种源自血小板的因子可刺激培养中的平滑肌细胞增殖，并且在体内刺激动脉粥样硬化形成过程中的平滑肌增殖性病变方面可能起重要作用。当从全血制备血清时，血小板因子在血小板聚集过程中产生。在体外，平滑肌细胞是血小板的强效聚集剂，而内皮细胞可抑制这种聚集作用。更好地理解血小板、平滑肌细胞和内皮之间的相互作用将有助于开发干预或预防动脉粥样硬化平滑肌增殖性病变的有效方法。
