排除=0数据的双指数拟合可提高肝脏IVIM参数测量的扫描-重扫稳定性，尤其是灌注分数的稳定性。

Bi-exponential fitting excluding =0 data improves the scan-rescan stability of liver IVIM parameter measures and particularly so for the perfusion fraction.

作者信息

Zheng Cun-Jing, Xiao Ben-Heng, Huang Hua, Zhou Nan, Yan Tai-Yu, Wáng Yì Xiáng J

机构信息

Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Department of Radiology, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, National Clinical Research Center for Infectious Diseases, Shenzhen, China.

出版信息

Quant Imaging Med Surg. 2022 Jun;12(6):3288-3299. doi: 10.21037/qims-2022-02.

DOI:10.21037/qims-2022-02

PMID:35655827

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9131351/

Abstract

BACKGROUND

A prerequisite to translating intravoxel incoherent motion (IVIM) imaging into meaningful clinical applications is sufficient scan-rescan reproducibility. This study aims to confirm the hypothesis that IVIM data fitting by not using =0 images will improve the stability of liver IVIM measurement.

METHODS

Healthy volunteers' liver IVIM images were prospectively acquired using a 1.5-T magnet or a 3.0 T with 16 -values. Repeatability study subjects were scanned twice during the same session, resulted in 35 paired scans for 35 subjects (11 men, mean age: 41.82 years, range: 32-60 years; 24 women, mean age: 42.67 years, range: 20-71 years). IVIM analysis was performed with full-fitting and segmented-fitting with a threshold -value of 60 s/mm, and fitting started from =0 s/mm or from =2 s/mm. Reproducibility study subjects were scanned and then rescanned with an interval of 5-18 days, resulted in 20 paired scans for 11 subjects (4 men, mean age: 26.25 years, range: 25-27 years; 7 women, mean age: 25.57 years, range: 24-27 years). IVIM analysis was performed with segmented-fitting with a threshold -value of 50 s/mm, and fitting started from =0 s/mm or from =3 s/mm.

RESULTS

Fitting without =0 data generally improved the repeatability and reproducibility for both PF and D, and particularly so for PF. For with =0 data segmented fitting repeatability, PF had within-subject standard deviation of 0.019, bland-Atman 75% agreement limit of -31.52% to 28.35%, and ICC of 0.647, while these values were 0.009, -20.78% to 16.86%, and 0.837 for without =0 analysis. Though the repeatability and reproducibility for D generally also improved, they remained suboptimal. Measurement stability was better for repeatability than for reproducibility.

CONCLUSIONS

Scan-rescan repeatability and reproducibility of liver IVIM parameters can be improved by fitting without =0 data, which is particularly so for PF.

摘要

背景

将体素内不相干运动（IVIM）成像转化为有意义的临床应用的一个前提条件是足够的扫描 - 重扫描可重复性。本研究旨在证实这一假设，即不使用(=0)图像进行IVIM数据拟合将提高肝脏IVIM测量的稳定性。

方法

前瞻性地使用1.5-T磁共振或3.0-T磁共振对健康志愿者的肝脏进行IVIM成像，共采集16个()值。重复性研究对象在同一时段内扫描两次，35名受试者（11名男性，平均年龄：41.82岁，范围：32 - 60岁；24名女性，平均年龄：42.67岁，范围：20 - 71岁）共获得35对扫描数据。IVIM分析采用全拟合和阈值()值为60 s/mm的分段拟合，拟合从(=0) s/mm或(=2) s/mm开始。再现性研究对象先进行扫描，然后在5 - 18天的间隔后再次扫描，11名受试者（4名男性，平均年龄：26.25岁，范围：25 - 27岁；7名女性，平均年龄：25.57岁，范围：24 - 27岁）共获得20对扫描数据。IVIM分析采用阈值()值为50 s/mm的分段拟合，拟合从(=0) s/mm或(=3) s/mm开始。