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慢性肾脏病中的血管钙化：最新进展与展望

Vascular Calcification in Chronic Kidney Disease: An Update and Perspective.

作者信息

Ren Si-Chong, Mao Nan, Yi Si, Ma Xin, Zou Jia-Qiong, Tang Xiaoqiang, Fan Jun-Ming

机构信息

1Chengdu Medical College, Chengdu, China.

2Department of Nephrology, First Affiliated Hospital of Chengdu Medical College, Chengdu, China.

出版信息

Aging Dis. 2022 Jun 1;13(3):673-697. doi: 10.14336/AD.2021.1024. eCollection 2022 Jun.

DOI:10.14336/AD.2021.1024
PMID:35656113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9116919/
Abstract

Chronic kidney disease is a devastating condition resulting from irreversible loss of nephron numbers and function and leading to end-stage renal disease and mineral disorders. Vascular calcification, an ectopic deposition of calcium-phosphate salts in blood vessel walls and heart valves, is an independent risk factor of cardiovascular morbidity and mortality in chronic kidney disease. Moreover, aging and related metabolic disorders are essential risk factors for chronic kidney disease and vascular calcification. Marked progress has been recently made in understanding and treating vascular calcification in chronic kidney disease. However, there is a paucity of systematic reviews summarizing this progress, and investigating unresolved issues is warranted. In this systematic review, we aimed to overview the underlying mechanisms of vascular calcification in chronic kidney diseases and discuss the impact of chronic kidney disease on the pathophysiology of vascular calcification. Additionally, we summarized potential clinical diagnostic biomarkers and therapeutic applications for vascular calcification with chronic kidney disease. This review may offer new insights into the pathogenesis, diagnosis, and therapeutic intervention of vascular calcification.

摘要

慢性肾脏病是一种由肾单位数量和功能不可逆转的丧失所导致的严重疾病，可发展为终末期肾病和矿物质紊乱。血管钙化是指磷酸钙盐在血管壁和心脏瓣膜中的异位沉积，是慢性肾脏病患者心血管发病和死亡的独立危险因素。此外，衰老及相关代谢紊乱是慢性肾脏病和血管钙化的重要危险因素。近年来，在慢性肾脏病血管钙化的认识和治疗方面取得了显著进展。然而，缺乏总结这一进展的系统综述，因此有必要对尚未解决的问题进行研究。在本系统综述中，我们旨在概述慢性肾脏病血管钙化的潜在机制，并讨论慢性肾脏病对血管钙化病理生理学的影响。此外，我们总结了慢性肾脏病血管钙化的潜在临床诊断生物标志物和治疗应用。本综述可能为血管钙化的发病机制、诊断和治疗干预提供新的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5364/9116919/736827fb47f8/AD-13-3-673-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5364/9116919/258911ab6434/AD-13-3-673-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5364/9116919/66b1341abef8/AD-13-3-673-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5364/9116919/e10979d17f12/AD-13-3-673-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5364/9116919/736827fb47f8/AD-13-3-673-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5364/9116919/258911ab6434/AD-13-3-673-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5364/9116919/66b1341abef8/AD-13-3-673-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5364/9116919/e10979d17f12/AD-13-3-673-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5364/9116919/736827fb47f8/AD-13-3-673-g4.jpg

相似文献

[1]
Vascular Calcification in Chronic Kidney Disease: An Update and Perspective.

Aging Dis. 2022-6-1

[2]
Vascular calcification in end-stage renal disease patients.

Contrib Nephrol. 2015

[3]
Osteopontin protects against high phosphate-induced nephrocalcinosis and vascular calcification.

Kidney Int. 2016-5

[4]
Aortic Calcification and Arterial Stiffness Burden in a Chronic Kidney Disease Cohort with High Cardiovascular Risk: Baseline Characteristics of the Impact of Phosphate Reduction On Vascular End-Points in Chronic Kidney Disease Trial.

Am J Nephrol. 2020

[5]
Arteriosclerosis, calcium phosphate deposition and cardiovascular disease in uremia: current concepts at the bench.

Curr Opin Nephrol Hypertens. 2005-11

[6]
Pathogenesis and Management of Vascular Calcification in Patients with End-Stage Renal Disease.

Contrib Nephrol. 2018

[7]
Mechanistic insights into CKD-MBD-related vascular calcification and its clinical implications.

Life Sci. 2022-12-15

[8]
Vascular calcification.

Curr Opin Nephrol Hypertens. 2005-7

[9]
Vascular calcification in chronic kidney disease: an update.

Nephrol Dial Transplant. 2015-4-26

[10]
[New mechanisms of chronic kidney disease-associated vascular calcification].

Sheng Li Xue Bao. 2022-12-25

引用本文的文献

[1]
Safety and efficacy of remote ischaemic preconditioning in diabetic kidney disease: a pilot randomised, parallel-arm, sham-controlled trial protocol.

BMJ Open. 2025-9-3

[2]
Pulse wave-driven machine learning for the non-invasive assessment of coronary artery calcification in patients with end-stage renal disease undergoing hemodialysis.

Biomed Eng Online. 2025-8-29

[3]
Predictive value of ferritin heavy chains in the development of coronary artery calcification in patients on maintenance hemodialysis: a prospective cohort study.

Front Endocrinol (Lausanne). 2025-7-30

[4]
Balancing accuracy and cost in machine learning models for detecting medial vascular calcification in chronic kidney disease: a pilot study.

Sci Rep. 2025-5-20

[5]
Exploring the association of calbindin -D28K in renal dialysis with oral health: a comprehensive review.

Front Oral Health. 2025-4-25

[6]
Evaluation of Individual Cardiovascular Risk in Pre-Dialysis CKD Patients by Using the Ratio of Calcium-Phosphorus Product to Estimated Glomerular Filtration Rate (Ca × P/eGFR).

Biomedicines. 2025-1-19

[7]
The Physiological Functions and Therapeutic Potential of Hypoxia-Inducible Factor-1α in Vascular Calcification.

Biomolecules. 2024-12-12

[8]
Alkaline phosphatase is associated with vascular depression in patients with severe white matter hyperintensities.

Front Neurosci. 2024-11-25

[9]
Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions.

Biomedicines. 2024-9-13

[10]
Association of plasma microRNA-16-5p and abdominal aortic calcification in maintenance hemodialysis patients.

Ren Fail. 2024-12

本文引用的文献

[1]
Short-chain fatty acids in blood pressure, friend or foe.

Chin Med J (Engl). 2021-6-30

[2]
Mitochondria Homeostasis and Vascular Medial Calcification.

Calcif Tissue Int. 2021-8

[3]
Klotho retards renal fibrosis through targeting mitochondrial dysfunction and cellular senescence in renal tubular cells.

Physiol Rep. 2021-1

[4]
The receptor activator of nuclear factor κΒ ligand receptor leucine-rich repeat-containing G-protein-coupled receptor 4 contributes to parathyroid hormone-induced vascular calcification.

Nephrol Dial Transplant. 2021-3-29

[5]
[Low serum Klotho level as a predictor of calcification of the heart and blood vessels in patients with CKD stages 2-5D].

Ter Arkh. 2020-7-9

[6]
The Crosstalk between Calcium Ions and Aldosterone Contributes to Inflammation, Apoptosis, and Calcification of VSMC via the AIF-1/NF-B Pathway in Uremia.

Oxid Med Cell Longev. 2020-12-4

[7]
The Protective Role of Klotho in CKD-Associated Cardiovascular Disease.

Kidney Dis (Basel). 2020-11

[8]
Vascular calcification relationship to vascular biomarkers and bone metabolism in advanced chronic kidney disease.

Bone. 2021-2

[9]
MicroRNAs are critical in regulating smooth muscle cell mineralization and apoptosis during vascular calcification.

J Cell Mol Med. 2020-12

[10]
Regulation of Vascular Calcification by Reactive Oxygen Species.

Antioxidants (Basel). 2020-10-8

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