Acar Ayda, Yoldas Ayse H, Turk Bengu G, Karaarslan Isil, Sagduyu Ilgen E, Ceylan Can, Unal Idil, Ozturk Gunseli
Department of Dermatology and Venereology, Ege University Medical Faculty, Izmir, Turkey.
Indian J Dermatol. 2022 Jan-Feb;67(1):12-18. doi: 10.4103/ijd.IJD_671_21.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute, life-threatening, severe drug reactions. Randomized studies on these diseases are difficult to perform.
The purpose of this study was to summarize the demographic and clinical characteristics of patients with SJS and TEN in a tertiary hospital in Turkey.
We evaluated the records of 33 patients with SJS and TEN who were followed in our clinic or examined between January 2008 and June 2019, retrospectively. Age, sex, time of admission to hospital, causative drug, presence of concomitant disease, skin findings, mucosal involvement, the severity-of-illness score for TEN, the medication used, antibiotic use, transfer to intensive care, development of complications, and death or discharge status were noted.
Of the 33 patients, 11 (33.3%) had SJS, 3 (9.1%) had SJS/TEN overlap, and 19 (57.6%) had TEN. The majority (60.6%) of the patients were female. Nineteen (57.6%) patients had one, and 13 (39.4%) had more than one suspected drug exposure in their history. The most commonly suspected drugs were antibiotics. Twelve (36.4%) patients had intensive care unit hospitalization. Ten (30.3%) patients died.
The demographic data of our study were consistent with the literature. Similar to the literature, antibiotics were the most common reaction-causing drugs. However, antiepileptic drugs, which were more frequently reported in other studies, were identified as suspicious in only one patient. We believe that our study will contribute to the determination of characteristics of this rare disease with real-life data.
史蒂文斯 - 约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是急性、危及生命的严重药物不良反应。针对这些疾病进行随机研究很困难。
本研究的目的是总结土耳其一家三级医院中SJS和TEN患者的人口统计学和临床特征。
我们回顾性评估了2008年1月至2019年6月期间在我们诊所就诊或接受检查的33例SJS和TEN患者的记录。记录了患者的年龄、性别、入院时间、致病药物、合并疾病情况、皮肤表现、黏膜受累情况、TEN疾病严重程度评分、使用的药物、抗生素使用情况、转入重症监护病房情况、并发症发生情况以及死亡或出院状态。
33例患者中，11例（33.3%）患有SJS，3例（9.1%）患有SJS/TEN重叠综合征，19例（57.6%）患有TEN。大多数患者（60.6%）为女性。19例（57.6%）患者有过一种，13例（39.4%）患者有过一种以上可疑药物暴露史。最常怀疑的药物是抗生素。12例（36.4%）患者入住了重症监护病房。10例（30.3%）患者死亡。
我们研究的人口统计学数据与文献一致。与文献相似，抗生素是最常见的引起反应的药物。然而，在其他研究中更频繁报道的抗癫痫药物，在我们的研究中仅在1例患者中被确定为可疑。我们相信我们的研究将有助于用实际生活数据确定这种罕见疾病的特征。
