儿童史蒂文斯-约翰逊综合征（SJS）、中毒性表皮坏死松解症（TEN）及SJS-TEN重叠综合征的致病药物与临床结局
Causative Drugs and Clinical Outcome in Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS-TEN Overlap in Children.
作者信息
Sethuraman Gomathy, Sharma Vinod K, Pahwa Pooja, Khetan Pooja
机构信息
Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
出版信息
Indian J Dermatol. 2012 May;57(3):199-200. doi: 10.4103/0019-5154.96192.
Abstract
BACKGROUND
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the most severe adverse drug reactions in children.
OBJECTIVES
The objective was to study the causative drugs and outcome in children with SJS, SJS-TEN overlap, and TEN.
MATERIALS AND METHODS
Retrospective analysis of all the in-patient records of children below 18 years of age with the diagnosis of SJS, SJS-TEN overlap, and TEN was carried out.
RESULTS AND CONCLUSIONS
Twenty children were identified, eight patients each were diagnosed as SJS and TEN and four as SJS-TEN overlap. Multiple drugs were implicated in 15 cases while single drug was responsible in 5 cases. Antibiotics (40.7%) were implicated as the commonest cause followed by NSAIDS (25.9%) and anticonvulsants (7.4%). Seventeen patients recovered completely and three patients died.
摘要
背景
史蒂文斯 - 约翰逊综合征（SJS）和中毒性表皮坏死松解症（TEN）是儿童最严重的药物不良反应。
目的
研究患SJS、SJS - TEN重叠综合征及TEN的儿童的致病药物及转归情况。
材料与方法
对所有诊断为SJS、SJS - TEN重叠综合征及TEN的18岁以下儿童住院记录进行回顾性分析。
结果与结论
共确定20例患儿，其中8例诊断为SJS，8例诊断为TEN，4例诊断为SJS - TEN重叠综合征。15例涉及多种药物，5例由单一药物引起。抗生素（40.7%）是最常见的病因，其次是非甾体抗炎药（25.9%）和抗惊厥药（7.4%）。17例患儿完全康复，3例死亡。
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