Zhu Wandi, Deo Rahul C, MacRae Calum A
Cardiovascular Medicine Division and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Front Pharmacol. 2022 May 17;13:867431. doi: 10.3389/fphar.2022.867431. eCollection 2022.
The full range of cell functions is under-determined in most human diseases. The evidence that somatic cell competition and clonal imbalance play a role in non-neoplastic chronic disease reveal a need for a dedicated effort to explore single cell function if we are to understand the mechanisms by which cell population behaviors influence disease. It will be vital to document not only the prevalent pathologic behaviors but also those beneficial functions eliminated or suppressed by competition. An improved mechanistic understanding of the role of somatic cell biology will help to stratify chronic disease, define more precisely at an individual level the role of environmental factors and establish principles for prevention and potential intervention throughout the life course and across the trajectory from wellness to disease.
在大多数人类疾病中，细胞功能的全貌尚未完全明确。体细胞竞争和克隆失衡在非肿瘤性慢性疾病中发挥作用的证据表明，如果我们想要理解细胞群体行为影响疾病的机制，就需要专门致力于探索单细胞功能。不仅记录普遍的病理行为，而且记录那些因竞争而被消除或抑制的有益功能，这将至关重要。对体细胞生物学作用的机制有更深入的理解，将有助于对慢性疾病进行分层，在个体层面更精确地界定环境因素的作用，并确立贯穿生命历程以及从健康到疾病轨迹的预防和潜在干预原则。
