Institute of Pharmaceutical Research, GLA University, Mathura, U.P., India.
CNS Neurol Disord Drug Targets. 2023;22(6):789-800. doi: 10.2174/1871527321666220602111935.
Brain disorders are currently one of the world's most serious and difficult health issues. These brain disorders are accountable for a massive number of morbidities and mortalities around the world. The current treatments of these disorders are frequently accompanied by severe side effects and cause a detrimental effect on health. Recently, plant flavonoids have sparked a surge in public and scientific attention because of their alleged health-promoting impact and almost no adverse repercussions. Also, scientific research has shown that phytochemicals possess numerous neuroprotective properties under in vivo and in vitro conditions. Chrysin is a therapeutic phytochemical that falls under the class of flavonoids based on its structure. The biological activities and pharmacological effects of chrysin include anticancer, antioxidant, and anti-inflammatory activities as well as amyloidogenic and neurotrophic effects. These therapeutic abilities of chrysin are attributed to its structural diverseness arising in ring-A and lack of oxygenation in B and C rings. Several studies have highlighted the rising significance of chrysin in a variety of brain illnesses, like Alzheimer's disease, Parkinson's disease, depression, anxiety, brain tumours, epilepsy, multiple sclerosis, traumatic brain injury, spinal cord injury, and ischemic stroke. This study depicts the relationship of chrysin with different brain-related disorders and discusses the mechanisms responsible for the potential role of chrysin as a pharmacological agent for the treatment and management of different brain disorders based on the results of several preclinical studies and taking into account the therapeutic effects of the compound.
脑疾病目前是全球最严重和困难的健康问题之一。这些脑疾病在全球范围内导致了大量的发病率和死亡率。目前这些疾病的治疗方法常常伴随着严重的副作用，对健康造成不利影响。最近，植物类黄酮因其据称的促进健康的影响和几乎没有不良反应而引起了公众和科学界的关注。此外，科学研究表明，植物化学物质在体内和体外条件下具有多种神经保护特性。白杨素是一种基于其结构的黄酮类治疗性植物化学物质。白杨素的生物活性和药理作用包括抗癌、抗氧化和抗炎活性以及淀粉样蛋白和神经营养作用。白杨素的这些治疗能力归因于其在环 A 中产生的结构多样性以及 B 和 C 环中缺乏氧化。多项研究强调了白杨素在多种脑疾病中的重要性，如阿尔茨海默病、帕金森病、抑郁症、焦虑症、脑肿瘤、癫痫、多发性硬化症、创伤性脑损伤、脊髓损伤和缺血性中风。本研究描述了白杨素与不同脑相关疾病的关系，并根据几项临床前研究的结果，讨论了白杨素作为治疗和管理不同脑疾病的药理学药物的潜在作用的机制，同时考虑到该化合物的治疗效果。
