HPSTD Outpatient Clinic, University Hospital of Dermatology Essen, University of Duisburg-Essen, Essen, Germany.
Institute for Translational HIV Research, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
J Dtsch Dermatol Ges. 2022 Jun;20(6):892-904. doi: 10.1111/ddg.14788. Epub 2022 Jun 3.
Kaposi's sarcoma (KS) is a rare, malignant, multilocular vascular disease originating from lymphatic endothelial cells that can primarily affect the skin and mucous membranes, but also the lymphatic system and internal organs such as the gastrointestinal tract, lungs or liver. Five epidemiological subtypes of KS with variable clinical course and prognosis are distinguished, with increased incidence in specific populations: (1) Classical KS, (2) Iatrogenic KS in immunosuppression, (3) Endemic (African) lymphadenopathic KS, (4) Epidemic, HIV-associated KS and KS associated with immune reconstitution inflammatory syndrome (IRIS), and (5) KS in men who have sex with men (MSM) without HIV infection. This interdisciplinary guideline summarizes current practice-relevant recommendations on diangostics and therapy of the different forms of KS. The recommendations mentioned in this short guideline are elaborated in more detail in the extended version of the guideline (online format of the JDDG).
卡波西肉瘤（KS）是一种罕见的、恶性的、多腔性血管疾病，起源于淋巴内皮细胞，主要影响皮肤和粘膜，但也影响淋巴系统和内部器官，如胃肠道、肺部或肝脏。KS 有五种不同的流行病学亚型，其临床表现和预后各不相同，在特定人群中发病率增加：（1）经典 KS；（2）免疫抑制治疗引起的 KS；（3）地方性（非洲）淋巴结病性 KS；（4）流行，与 HIV 相关的 KS 和与免疫重建炎症综合征（IRIS）相关的 KS；（5）与 HIV 感染无关的男男性行为者（MSM）中的 KS。本跨学科指南总结了不同形式 KS 的诊断和治疗的当前实践相关建议。本简短指南中提到的建议在指南的扩展版本（JDDG 的在线格式）中详细阐述。
