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冠状动脉搭桥手术的价值。心脏病学争议:第一部分。

Value of coronary bypass surgery. Controversies in cardiology: Part I.

作者信息

Hurst J W, King S B, Logue R B, Hatcher C R, Jones E L, Craver J M, Douglas J S, Franch R H, Dorney E R, Cobbs B W, Robinson P H, Clements S D, Kaplan J A, Bradford J M

出版信息

Am J Cardiol. 1978 Aug;42(2):308-29. doi: 10.1016/0002-9149(78)90917-7.

Abstract

The value of coronary bypass surgery has been studied carefully during the last decade. Four methods, none perfect, have been used to compare the results of such surgery with the results of medical therapy. New data are likely to be merely supportive rather than the outcome of a definitive study with a new and a acceptable experimental design. It is therefore time to analyze the available data in light of the treacherousness of the disease and to determine if a clear trend is evident. There appears to be sufficient evidence to state that properly performed coronary bypass surgery will increase coronary blood flow and relieve angina pectoris in 90 percent of patients; total relief of angina can be expected in 60 percent and partial relief in 30 percent. Compared with modern medical therapy, properly performed coronary bypass surgery appears to prolong the life of patients who have obstruction of the left main coronary artery or triple or double vessel disease. There is not adequate evidence to state that the procedure will prolong the life of patients with single vessel obstruction. However, patients with single vessel obstruction and unacceptable angina pectoris should be considered for bypass surgery (especially patients with obstruction of the left anterior descending coronary artery). In practice, at Emory University Hospital, Atlanta, bypass surgery is recommended for young people with few symptoms if compelling obstructing lesions are present and in older patients only if their symptoms require it. Medical therapy is given before and after bypass surgery. When bypass surgery is performed in an excellent fashion (operative risk 1 percent) a great deal of "controversy" about this problem vanishes.

摘要

在过去十年中,人们对冠状动脉搭桥手术的价值进行了仔细研究。已采用四种方法(无一完美)来比较这种手术与药物治疗的结果。新数据可能只是起到支持作用,而不是来自具有全新且可接受的实验设计的确定性研究结果。因此,现在是时候根据该疾病的凶险程度来分析现有数据,并确定是否有明显的趋势。似乎有足够的证据表明,正确实施的冠状动脉搭桥手术将增加冠状动脉血流量,并使90%的患者缓解心绞痛;预计60%的患者心绞痛能完全缓解,30%的患者部分缓解。与现代药物治疗相比,正确实施的冠状动脉搭桥手术似乎能延长左主干冠状动脉阻塞或三支或双支血管病变患者的寿命。没有足够的证据表明该手术能延长单支血管阻塞患者的寿命。然而,对于单支血管阻塞且心绞痛难以忍受的患者,应考虑进行搭桥手术(特别是左前降支冠状动脉阻塞的患者)。实际上,在亚特兰大的埃默里大学医院,如果存在明显的阻塞性病变,对于症状较少的年轻人建议进行搭桥手术,而对于老年患者,只有在症状需要时才进行。在搭桥手术前后都要进行药物治疗。当以极高的水准实施搭桥手术(手术风险为1%)时,关于这个问题的大量“争议”就会消失。

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