Díez-Gómez M L, Hinojosa M, Moneo I, Losada E
Allergy. 1987 Jan;42(1):74-6. doi: 10.1111/j.1398-9995.1987.tb02190.x.
Orgotein, a recently introduced anti-inflammatory agent, is the generic name accepted in the U.S.A. for the drug version of copper-zinc superoxide dismutase. This metallo-enzyme is obtained from bovine liver and has a molecular weight of about 32,000. We report on a patient to whom an intra-articular injection of orgotein caused an anaphylactic reaction. An IgE-mediated mechanism was suggested by an immediate positive skin test to orgotein and by the finding of specific IgE against orgotein in the patient's serum.
奥古蛋白是一种最近推出的抗炎药，是美国对铜锌超氧化物歧化酶药物版本所采用的通用名称。这种金属酶从牛肝脏中提取，分子量约为32,000。我们报告了一名患者，关节内注射奥古蛋白后发生了过敏反应。对奥古蛋白立即呈阳性的皮肤试验以及在患者血清中发现针对奥古蛋白的特异性IgE提示了一种IgE介导的机制。
